4-(5-苯基-噻唑-2-基)-吡啶 | 106950-02-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-(5-苯基-噻唑-2-基)-吡啶
• 英文名称: 4-(5-phenyl-thiazol-2-yl)-pyridine
• 英文别名: 4-(5-Phenyl-thiazol-2-yl)-pyridin；5-Phenyl-2-pyridin-4-yl-1,3-thiazole
• CAS: 106950-02-1
• 化学式: C₁₄H₁₀N₂S
• 分子量: 238.313
• InChiKey: NXFTZOANPXPAJL-UHFFFAOYSA-N

物化性质

• 熔点：
  240-242 °C
• 沸点：
  444.3±47.0 °C(Predicted)
• 密度：
  1.216±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(5-苯基-噻唑-2-基)-吡啶 以40%的产率得到
  参考文献：
  名称：

  AL-AZAWE, SUBHI S., J. IRAQI CHEM. SOC., 13,(1988) N, C. 1-13

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(phenacyl)isonicotinamide 在 tetraphosphorus decasulfide 作用下， 生成 4-(5-苯基-噻唑-2-基)-吡啶
  参考文献：
  名称：

  Liquid Scintillators. VIII. The Effect of the Dialkylamino Group¹

  摘要：

  DOI：

  10.1021/jo01094a007

文献信息

• Programmed synthesis of arylthiazoles through sequential C–H couplings
  作者：Satoshi Tani、Takahiro N. Uehara、Junichiro Yamaguchi、Kenichiro Itami

  DOI：10.1039/c3sc52199k

  日期：——

  A programmed synthesis of privileged arylthiazoles via sequential C–H couplings catalyzed by palladium or nickel catalysts has been accomplished. This versatile protocol can supply all possible arylthiazole substitution patterns (2-aryl, 4-aryl, 5-aryl, 2,4-diaryl, 2,5-diaryl, 4,5-diaryl, and 2,4,5-triaryl) from an unfunctionalized thiazole platform by 11 distinct synthetic routes. We have generated

  特权arylthiazoles的编程合成通过由钯或镍催化剂催化顺序C-H偶合已经完成。该通用协议可提供所有可能的芳基噻唑取代方式（2-芳基，4-芳基，5-芳基，2,4-二芳基，2,5-二芳基，4,5-二芳基和2,4,5-三芳基）通过11种不同的合成途径从未官能化的噻唑平台上合成 使用这种方法，我们已经生成了150多种芳基噻唑。我们已经将该方法应用于脂肪抑制素（SREBP抑制剂）的快速合成，并且已证明克级合成三芳基噻唑。
• [EN] LIGHT-EMITTING COMPOSITION<br/>[FR] COMPOSITION ÉLECTROLUMINESCENTE
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2021069902A1

  公开（公告）日：2021-04-15

  A light-emitting composition containing first and second light-emitting markers. The first light-emitting marker comprises a first light-emitting material and a first binding group configured to bind to a first target analyte. The second light-emitting marker comprises a second light-emitting material which is different from the first light- emitting material and a second binding group which is different from the first binding group and which is configured to bind to a second target analyte. A luminescent lifetime of the first light-emitting material is shorter than a luminescent lifetime of the second light-emitting material. The difference in lifetimes of the first and second light- emitting materials may be used to distinguish between the first and second target analytes in a sample, e.g. by time-gated flow cytometry.
• [EN] METHOD COMPRISING LIGHT EMITTING MARKER<br/>[FR] PROCÉDÉ COMPRENANT UN MARQUEUR ÉLECTROLUMINESCENT
  申请人：[en]CAMBRIDGE DISPLAY TECHNOLOGY LIMITED

  公开号：WO2022079005A1

  公开（公告）日：2022-04-21

  A method of determining whether a test nucleotide comprises a base complementary to the next base of a template strand immediately downstream of a primer in a primed template nucleic acid molecule is described. The method comprises the use of a marked nucleotide comprising a test nucleotide conjugated to a light emitting marker by a linker.