(S)-3-{[2-(4,5-Diphenyloxazol-2-yl)-2-cyclopenten-1-yl]-methyl}phenyl trifluoromethanesulfonate | 217318-89-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (S)-3-{[2-(4,5-Diphenyloxazol-2-yl)-2-cyclopenten-1-yl]-methyl}phenyl trifluoromethanesulfonate
• 英文别名: [3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cyclopent-2-en-1-yl]methyl]phenyl] trifluoromethanesulfonate
• CAS: 217318-89-3
• 化学式: C₂₈H₂₂F₃NO₄S
• 分子量: 525.548
• InChiKey: AIPSBHOMDUSBTQ-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  77.8
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• OXAZOLE COMPOUNDS USEFUL AS PGE2 AGONISTS AND ANTAGONISTS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0989975A1

  公开（公告）日：2000-04-05
• US6245790B1
  申请人：——

  公开号：US6245790B1

  公开（公告）日：2001-06-12
• [EN] OXAZOLE COMPOUNDS USEFUL AS PGE2 AGONISTS AND ANTAGONISTS<br/>[FR] COMPOSES D'OXAZOLE UTILES COMME AGONISTES ET ANTAGONISTES DE LA PROSTAGLANDINE E2
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：WO1998055468A1

  公开（公告）日：1998-12-10

  (EN) Azole compounds of formula (I) wherein R1 is lower alkyl substituted with carboxy, etc., R2 is hydrogen or lower alkyl, R3 is aryl, etc., R4 is aryl, etc., Q is formula (a), etc., and X is O, NH or S, and its salts, which are useful as medicament.(FR) L'invention concerne des composés d'azole de la formule (I), dans laquelle R1 est alkyle inférieur substitué avec carboxy, etc., R2 est hydrogène ou alkyle inférieur, R3 est aryle, etc., R4 est aryle, etc., Q est (a), etc., et X est O, NH ou S, ainsi que ses sels, qui sont utiles comme médicament.
• [EN] NEW USE OF PROSTAGLANDIN E2 ANTAGONISTS<br/>[FR] NOUVELLE UTILISATION DES ANTAGONISTES DE LA PROSTAGLANDINE E2
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2000016760A2

  公开（公告）日：2000-03-30

  Prostaglandin E2 receptor blockets, particularly EP4 receptor blocker, have diuretic activity with a various characteristics such as a lower kaluretic activity relative to natriuretic effect, a larger phosphorus excretion, or the like. Therefore, they are useful for preparation of medicament indicated treating or preventing various edema, hypertension, premenstrual tension, urinary calculus, oliguria, hyperphosphaturia, or the like.