硫酸紫霉素 | 37883-00-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 中文名称: 硫酸紫霉素
• 中文别名: 紫霉素硫酸盐
• 英文名称: Viomycin sulfate, United States PharmacopeiaReference Standard
• 英文别名: [(3S)-6-amino-1-[[(3S,6Z,9S,12S,15S)-3-[(4R,6S)-2-amino-6-hydroxy-1,4,5,6-tetrahydropyrimidin-3-ium-4-yl]-6-[(carbamoylamino)methylidene]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclohexadec-15-yl]amino]-1-oxohexan-3-yl]azanium;sulfate
• CAS: 37883-00-4
• 化学式: C25H45N13O14S
• 分子量: 783.8
• InChiKey: AQONYROJHRNYQQ-QMAPKBLTSA-N

物化性质

• 熔点：
  266° (dec)
• 比旋光度：
  D18 -29.5° (c = 1 in H2O)

计算性质

• 辛醇/水分配系数(LogP)：
  -9.54
• 重原子数：
  53
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  476
• 氢给体数：
  17
• 氢受体数：
  17

安全信息

• 危险等级：
  6.1(b)
• 危险品标志：
  T
• 安全说明：
  S22,S36/37,S45,S53
• 危险类别码：
  R61,R20/21/22
• 包装等级：
  III
• 危险类别：
  6.1(b)

文献信息

• METHODS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150238473A1

  公开（公告）日：2015-08-27

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• RIBOSOME STRUCTURE AND PROTEIN SYNTHESIS INHIBITORS
  申请人：Steitz A. Thomas

  公开号：US20050036997A1

  公开（公告）日：2005-02-17

  The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

  本发明提供了生产核糖体和核糖体亚基高分辨率晶体的方法，以及由这些方法产生的晶体。该发明还提供了核糖体亚基的高分辨率结构，无论是单独还是与蛋白质合成抑制剂结合。该发明提供了用于识别与核糖体相关的配体的方法，以及设计具有特定核糖体结合性质的配体的方法，以及可能起作用为蛋白质合成抑制剂的配体。因此，本发明的方法和组合物可用于生产专门设计用于杀灭或抑制任何目标生物生长的配体。
• Ribosome structure and protein synthesis inhibitors
  申请人：Steitz A. Thomas

  公开号：US20050272681A1

  公开（公告）日：2005-12-08

  The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

  本发明提供了制备高分辨率核糖体和核糖体亚基晶体的方法，以及由这些方法产生的晶体。本发明还提供了核糖体亚基的高分辨率结构，无论是单独还是与蛋白质合成抑制剂结合。本发明提供了识别与核糖体相关的配体的方法，以及设计具有特定核糖体结合性质的配体的方法，以及可能作为蛋白质合成抑制剂的配体。因此，本发明的方法和组合物可用于生产旨在特异性杀死或抑制任何目标生物生长的配体。
• Ribosome Structure and Protein Synthesis Inhibitors
  申请人：Steitz Thomas

  公开号：US20100204253A1

  公开（公告）日：2010-08-12

  The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

  该发明提供了制备高分辨率核糖体和核糖体亚基晶体的方法，以及由这些方法制备的晶体。该发明还提供了核糖体亚基的高分辨率结构，无论是单独还是与蛋白质合成抑制剂结合。该发明提供了识别与核糖体相关的配体的方法，以及设计具有特定核糖体结合性质的配体和可能作为蛋白质合成抑制剂的配体的方法。因此，该发明的方法和组合物可用于生产旨在特异性杀死或抑制任何目标生物生长的配体。
• Urethral catheter capable of preventing urinary tract infection and process for producing the same
  申请人：UNITIKA LTD.

  公开号：EP0065884A1

  公开（公告）日：1982-12-01

  A urethral catheter composed of olefin polymer, diene polymer or silicone polymer as a base material wherein an antimicrobial substance being chemically bonded with the inside wall and/or the outside wall thereof, and a process for producing the same. This urethral catheter effectively prevents urinary tract infection for a long period of time.

  一种以烯烃聚合物、二烯聚合物或硅酮聚合物为基材，在其内壁和/或外壁化学键合抗菌物质的尿道导管及其生产工艺。 这种尿道导管可长期有效地防止尿路感染。