4-amino-2-ethyl-5-methyl-2H-pyrazole-3-carboxylic acid | 26308-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-amino-2-ethyl-5-methyl-2H-pyrazole-3-carboxylic acid
• 英文别名: 4-amino-1-ethyl-3-methyl-1H-pyrazole-5-carboxylic acid；4-amino-2-ethyl-5-methylpyrazole-3-carboxylic acid
• CAS: 26308-45-2
• 化学式: C₇H₁₁N₃O₂
• 分子量: 169.183
• InChiKey: KKKAWBDMVLFWNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• MACROCYCLES AS PDE1 INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：US20190185489A1

  公开（公告）日：2019-06-20

  The present invention provides macrocycles of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

  本发明提供了式(I)的大环化合物作为PDE1抑制剂，并将其用作药物，特别用于治疗神经退行性疾病和精神疾病。
• 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：US20190194189A1

  公开（公告）日：2019-06-27

  The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

  本发明提供了式(I)的1H-吡唑并[4,3-b]吡啶类化合物作为PDE1抑制剂，并将其用作药物，特别用于治疗神经退行性疾病和精神疾病。
• Macrocycles as PDE1 inhibitors
  申请人：H. Lundbeck A/S

  公开号：US10618913B2

  公开（公告）日：2020-04-14

  The present invention provides macrocycles of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

  本发明提供了作为 PDE1 抑制剂的式 (I) 大环及其作为药物的用途，特别是用于治疗神经退行性疾病和精神疾病。
• 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
  申请人：H. Lundbeck A/S

  公开号：US10766893B2

  公开（公告）日：2020-09-08

  The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

  本发明提供了作为 PDE1 抑制剂的式 (I) 的 1H-吡唑并[4,3-b]吡啶及其作为药物的用途，特别是用于治疗神经退行性疾病和精神疾病。
• COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES
  申请人：H. Lundbeck A/S

  公开号：EP3723807B1

  公开（公告）日：2021-10-20