N,N,N'-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-N'-(t-butyloxycarbonylmethyl)ethylenediamine | 439614-48-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N,N'-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-N'-(t-butyloxycarbonylmethyl)ethylenediamine
• 英文别名: Tert-butyl 2-[2-[bis[[6-(6-bromopyridin-2-yl)pyridin-3-yl]methyl]amino]ethyl-[[6-(6-bromopyridin-2-yl)pyridin-3-yl]methyl]amino]acetate
• CAS: 439614-48-9
• 化学式: C₄₁H₃₉Br₃N₈O₂
• 分子量: 915.525
• InChiKey: HEUBRGSVAWEBEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  54
• 可旋转键数：
  16
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  110
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N,N,N'-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-N'-(t-butyloxycarbonylmethyl)ethylenediamine 在 bis-triphenylphosphine-palladium(II) chloride sodium hydroxide 、 三乙胺 作用下， 以 甲醇 、 水 为溶剂， 80.0 ℃ 、101.33 kPa 条件下， 反应 1.0h， 生成 N,N,N'-tris[(6-carboxy-2,2'-bipyridine-5'-yl)methyl]-N'-(carboxymethyl)ethylenediamine
  参考文献：
  名称：

  5‘-Substituted-6-carboxylic-2,2‘-bipyridine Acid:  A Pivotal Architecton for Building Preorganized Ligands

  摘要：

  A set of ligands bearing 6-bromo-2,2'-bipyridine pendant arms attached in the 5'-position are described. Trans formation of the bromo to an ester was performed by a carboethoxylation reaction promoted by low-valent Pd(0), while saponification followed by acidification gave the acids. The introduction of an appended function 3-nitrobenzyl, benzamidomethyl, and tert-butylacetyl opens the way to further functionalize these scaffolds for potential labeling of biological material. The synthetic protocols represent a valuable approach to the rational design of ligands bearing oxophilic and anionic sidearms.

  DOI：

  10.1021/jo0200015
• 作为产物：
  描述：

  (2-氨基乙基氨基)乙酸叔丁酯 、 6-bromo-5'-bromomethyl-2,2'-bipyridine 在 sodium carbonate 作用下， 以 乙腈 为溶剂， 反应 22.0h， 以85%的产率得到N,N,N'-tris[(6-bromo-2,2'-bipyridine-5'-yl)methyl]-N'-(t-butyloxycarbonylmethyl)ethylenediamine
  参考文献：
  名称：

  5‘-Substituted-6-carboxylic-2,2‘-bipyridine Acid:  A Pivotal Architecton for Building Preorganized Ligands

  摘要：

  A set of ligands bearing 6-bromo-2,2'-bipyridine pendant arms attached in the 5'-position are described. Trans formation of the bromo to an ester was performed by a carboethoxylation reaction promoted by low-valent Pd(0), while saponification followed by acidification gave the acids. The introduction of an appended function 3-nitrobenzyl, benzamidomethyl, and tert-butylacetyl opens the way to further functionalize these scaffolds for potential labeling of biological material. The synthetic protocols represent a valuable approach to the rational design of ligands bearing oxophilic and anionic sidearms.

  DOI：

  10.1021/jo0200015

文献信息

• 5‘-Substituted-6-carboxylic-2,2‘-bipyridine Acid:  A Pivotal Architecton for Building Preorganized Ligands
  作者：Loïc J. Charbonnière、Nicolas Weibel、Raymond F. Ziessel

  DOI：10.1021/jo0200015

  日期：2002.5.1

  A set of ligands bearing 6-bromo-2,2'-bipyridine pendant arms attached in the 5'-position are described. Trans formation of the bromo to an ester was performed by a carboethoxylation reaction promoted by low-valent Pd(0), while saponification followed by acidification gave the acids. The introduction of an appended function 3-nitrobenzyl, benzamidomethyl, and tert-butylacetyl opens the way to further functionalize these scaffolds for potential labeling of biological material. The synthetic protocols represent a valuable approach to the rational design of ligands bearing oxophilic and anionic sidearms.