1,1'-diethyl-5,5'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-4,4'-disulfanediyl-bis-pyrazol-3-one | 138740-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,1'-diethyl-5,5'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-4,4'-disulfanediyl-bis-pyrazol-3-one
• 英文别名: 1,1'-Diaethyl-5,5'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-4,4'-disulfandiyl-bis-pyrazol-3-on；1-Ethyl-4-[(1-ethyl-5-methyl-3-oxo-2-phenylpyrazol-4-yl)disulfanyl]-5-methyl-2-phenylpyrazol-3-one
• CAS: 138740-43-9
• 化学式: C₂₄H₂₆N₄O₂S₂
• 分子量: 466.628
• InChiKey: HUAMYGPFSKGTKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  97.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 二氯化二硫 、 四氯化碳 、 氯仿 作用下， 生成 1,1'-diethyl-5,5'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-4,4'-disulfanediyl-bis-pyrazol-3-one
  参考文献：
  名称：

  Age-Related Deterioration of Coordinated Interlimb Behavior

  摘要：

  Younger and older participants performed two-limb coordination patterns of homologous (similar) and nonhomologous (dissimilar) effecters during 1:1 synchronization, according to the in-phase or anti-phase mode. The aim of the study was to examine age-related changes during the production of these basic movement patterns and their relative stability difference. The findings revealed that the aging process modulated the coordination dynamics as a function of effector system characteristics. Whereas the homologous system was resistant to age-related deficits, movements of the nonhomologous system showed coordinative degradation that was most apparent during execution of the anti-phase mode. The latter performance regression is argued to be an expression of age-dependent declines in cognitive regulation and afferent information processing. This implies that deterioration in coordinated behavior across the Life span may be strongly task dependent because of a combined effect of cognitive and sensory components.

  DOI：

  10.1093/geronb/55.5.p295

文献信息

• US5063245A
  申请人：——

  公开号：US5063245A

  公开（公告）日：1991-11-05
• Age-Related Deterioration of Coordinated Interlimb Behavior
  作者：D. J. Serrien、S. P. Swinnen、G. E. Stelmach

  DOI：10.1093/geronb/55.5.p295

  日期：2000.9.1

  Younger and older participants performed two-limb coordination patterns of homologous (similar) and nonhomologous (dissimilar) effecters during 1:1 synchronization, according to the in-phase or anti-phase mode. The aim of the study was to examine age-related changes during the production of these basic movement patterns and their relative stability difference. The findings revealed that the aging process modulated the coordination dynamics as a function of effector system characteristics. Whereas the homologous system was resistant to age-related deficits, movements of the nonhomologous system showed coordinative degradation that was most apparent during execution of the anti-phase mode. The latter performance regression is argued to be an expression of age-dependent declines in cognitive regulation and afferent information processing. This implies that deterioration in coordinated behavior across the Life span may be strongly task dependent because of a combined effect of cognitive and sensory components.