2-((4-(1-Hydroxy-1-phenylmethyl)phenyl)sulfonyl-methyl)-5-phenylpentanoic Acid N-Hydroxy Amide | 203249-09-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((4-(1-Hydroxy-1-phenylmethyl)phenyl)sulfonyl-methyl)-5-phenylpentanoic Acid N-Hydroxy Amide
• 英文别名: 2-((4-(1-Hydroxy-1-phenylmethyl)phenyl)sulfonylmethyl)-5-phenylpentanoic Acid N-Hydroxy Amide；2-[4-(Hydroxy-phenyl-methyl)-benzenesulfonylmethyl]-5-phenyl-pentanoic acid hydroxyamide；N-hydroxy-2-[[4-[hydroxy(phenyl)methyl]phenyl]sulfonylmethyl]-5-phenylpentanamide
• CAS: 203249-09-6
• 化学式: C₂₅H₂₇NO₅S
• 分子量: 453.559
• InChiKey: SCDTVKKBOXTTSJ-UHFFFAOYSA-N

物化性质

• 密度：
  1.274±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-((4-(1-Hydroxy-1-phenylmethyl)phenyl)sulfonyl-methyl)-5-phenylpentanoic Acid N-Hydroxy Amide 在 三乙基硅烷 、 三氟乙酸 作用下， 生成 5-Phenyl-2-(4-(phenylmethyl)phenylsulfonylmethyl)pentanoic Acid N-Hydroxy Amide
  参考文献：
  名称：

  Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors

  摘要：

  A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00259-1
• 作为产物：
  描述：

  2-methylene-5-phenylpentanoic acid 在 盐酸 、 Oxone 、 sodium tetrahydroborate 、 氢溴酸 、 溶剂黄146 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 甲醇 、 乙醚 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-((4-(1-Hydroxy-1-phenylmethyl)phenyl)sulfonyl-methyl)-5-phenylpentanoic Acid N-Hydroxy Amide
  参考文献：
  名称：

  Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors

  摘要：

  A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00259-1

文献信息

• Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
  申请人：Darwin Discovery Ltd.

  公开号：US06566384B1

  公开（公告）日：2003-05-20

  Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.

  羟基酰胺和羧酸衍生物具有MMP和TNF抑制活性。
• Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory
  申请人：Darwin Discovery, Ltd.

  公开号：US06118001A1

  公开（公告）日：2000-09-12

  Disclosed are hydroxamic and carboxylic acid derivatives which are useful inhibitors of matrix metalloproteinase and/or TNF.alpha.-mediated diseases, including degenerative diseases and certain cancers.

  本发明揭示了羟肟酸和羧酸衍生物，它们是有用的基质金属蛋白酶和/或TNFα介导的疾病的抑制剂，包括退行性疾病和某些癌症。
• Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors
  作者：Andrew D Baxter、Ranjev Bhogal、John Bird、John F Keily、David T Manallack、John G Montana、David A Owen、William R Pitt、Robert J Watson、Ruth E Wills

  DOI：10.1016/s0960-894x(01)00259-1

  日期：2001.6

  A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer. (C) 2001 Elsevier Science Ltd. All rights reserved.