4-cyclopropyl-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)benzamide | 1610610-66-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-cyclopropyl-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-yl)benzamide
• 英文别名: 4-cyclopropyl-N-methyl-N-[3-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyridin-5-yl]benzamide
• CAS: 1610610-66-6
• 化学式: C₂₅H₂₀F₃N₃O
• 分子量: 435.449
• InChiKey: OBTXCMGPGHMGIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  37.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES PARASITAIRES
  申请人：IRM LLC

  公开号：WO2014078802A1

  公开（公告）日：2014-05-22

  The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

  本发明提供了化合物的公式I：[在此插入公式]或其药学上可接受的盐、互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的药物组合物以及使用这种化合物用于治疗、预防、抑制、改善或根除由疟原虫引起的疾病的病理学和/或症状学的方法，例如疟疾。
• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
  申请人：Chatterjee Arnab Kumar

  公开号：US20140155367A1

  公开（公告）日：2014-06-05

  The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

  本发明提供了式I的化合物：或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的制药组合物以及使用这种化合物治疗、预防、抑制、改善或根除由疟原虫（如疟疾）引起的病理和/或症状的方法。
• Foaming composition with wettability modifying and corrosion inhibitory properties for high temperature and ultra-high salinity
  申请人：Instituto Mexicano Del Petróleo

  公开号：EP2740781A1

  公开（公告）日：2014-06-11

  The present invention relates to obtaining and using foaming compositions with wettability-modifying and corrosion inhibitory properties that control the channeling of fluids in naturally fractured carbonate reservoirs, favorably alter the rock wettability in crude oil enhanced recovery processes and control uniform corrosion problems occurring in production rigs under high temperature and ultra-high salinity conditions; by means of the synergistic effect resulting from the supramolecular interaction of alkyl amido propyl hydroxysultaines or alkyl hydroxysultaines with sodium alkyl hydroxysulfonates and sodium alkenyl sulfonates (1). The foaming compositions with wettability-modifying and corrosion inhibitory properties are characterized for being tolerant to high concentrations of divalent ions such as calcium, magnesium, strontium and barium and for the fact that for their application in the reservoir, seawater and/or congenital water characteristic of the reservoir may be used as means of transportation.

  本发明涉及获得和使用具有润湿性改良和腐蚀抑制特性的发泡组合物，该组合物可控制天然裂缝碳酸盐储层中的流体通道，有利地改变原油提高采收率过程中的岩石润湿性，并控制高温和超高盐度条件下生产钻机中出现的均匀腐蚀问题；通过烷基酰胺丙基羟基磺烷或烷基羟基磺烷与烷基羟基磺酸钠和烯基磺酸钠的超分子相互作用产生的协同效应（1）。具有润湿改性和缓蚀特性的发泡组合物的特点是能够耐受高浓度的钙、镁、锶和钡等二价离子，而且在储层中应用时，可以使用海水和/或储层特有的先天性水作为运输工具。
• FOAMING COMPOSITION WITH WETTABILITY MODIFYING AND CORROSION INHIBITORY PROPERTIES FOR HIGH TEMPERATURE AND ULTRA-HIGH SALINITY
  申请人：Instituto Mexicano Del Petróleo

  公开号：EP2740781B1

  公开（公告）日：2015-12-30
• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS
  申请人：Novartis AG

  公开号：EP3405468A1

  公开（公告）日：2018-11-28