N-({4-[bis-(2-chloro-ethyl)-amino]-phenyl}-acetyl)-glycine methyl ester | 109403-20-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-({4-[bis-(2-chloro-ethyl)-amino]-phenyl}-acetyl)-glycine methyl ester
• 英文别名: N-({4-[Bis-(2-chlor-aethyl)-amino]-phenyl}-acetyl)-glycin-methylester
• CAS: 109403-20-5
• 化学式: C₁₅H₂₀Cl₂N₂O₃
• 分子量: 347.241
• InChiKey: XRQKVJHLNHZFNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22.0
• 可旋转键数：
  9.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  58.64
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  甘胺酸甲酯 、 (4-(二(2-氯乙基)氨基)苯基)乙酸 在 氯仿 、 N,N'-二环己基碳二亚胺 作用下， 生成 N-({4-[bis-(2-chloro-ethyl)-amino]-phenyl}-acetyl)-glycine methyl ester
  参考文献：
  名称：

  Isolated Noncompaction of the Ventricular Myocardium: Clinical and Molecular Aspects of a Rare Cardiomyopathy

  摘要：

  Isolated noncompaction of the ventricular myocardium (INVM) is a rare congenital heart disease that results from an abnormal arrest in endomyocardial embryogenesis. It is characterized by the presence of prominent ventricular myocardial trabeculations and deep intertrabecular recesses, in the absence of other structural heart defects. INVM was initially described in the pediatric population (Chin et al, 1990), but it has also been recognized more recently in adults (Oechslin et al, 2000; Ritter et al, 1997). We present a case of a 35-year-old woman with clinical and echocardiographic features of INVM who underwent cardiac transplantation in our institution. The literature on cardiac embryogenesis and development, with an emphasis on the different genetic factors that lead to noncompaction of the ventricular myocardium, is also reviewed.

  DOI：

  10.1038/labinvest.3780404