3-(1-Cyclopropyl-5-methoxy-3-methylideneinden-2-yl)-1-methylindole | 1396763-72-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(1-Cyclopropyl-5-methoxy-3-methylideneinden-2-yl)-1-methylindole
• 英文别名: 3-(1-cyclopropyl-5-methoxy-3-methylideneinden-2-yl)-1-methylindole
• CAS: 1396763-72-6
• 化学式: C₂₃H₂₁NO
• 分子量: 327.426
• InChiKey: VRIQLSOISCXEGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  14.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-cyclopropyl-4-(4-methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)but-2-yn-1-ol 在 (PhO)3PAuCl 、 双三氟甲烷磺酰亚胺银盐 作用下， 以 二氯甲烷 为溶剂， 以45%的产率得到3-(1-Cyclopropyl-5-methoxy-3-methylideneinden-2-yl)-1-methylindole
  参考文献：
  名称：

  Synthesis of 2-Indol-3-ylbenzofulvenes through a Tandem Reaction Catalyzed by Cationic Gold(I) Complexes

  摘要：

  A new access to benzofulvenes bearing an indol-3-yl substituent at C-2 has been developed. Treatment of 3-propargylindoles possessing an additional hydroxy group at the other propargylic position with a cationic gold(I) complex triggers a tandem 1,2-indole migration/aura-iso-Nazarov cyclization/elimination sequence that takes place under mild conditions.

  DOI：

  10.1055/s-0031-1290950

文献信息

• Synthesis of 2-Indol-3-ylbenzofulvenes through a Tandem Reaction Catalyzed by Cationic Gold(I) Complexes
  作者：Roberto Sanz、Estela Álvarez、Delia Miguel、Patricia García-García、Manuel Fernández-Rodríguez、Félix Rodríguez

  DOI：10.1055/s-0031-1290950

  日期：2012.6

  A new access to benzofulvenes bearing an indol-3-yl substituent at C-2 has been developed. Treatment of 3-propargylindoles possessing an additional hydroxy group at the other propargylic position with a cationic gold(I) complex triggers a tandem 1,2-indole migration/aura-iso-Nazarov cyclization/elimination sequence that takes place under mild conditions.