6-(3-Fluoropyridin-4-yl)-3-methyl-2-[4-(4-phenyl-1,2,4-triazol-3-yl)piperidin-1-yl]pyrimidin-4-one | 881917-70-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-(3-Fluoropyridin-4-yl)-3-methyl-2-[4-(4-phenyl-1,2,4-triazol-3-yl)piperidin-1-yl]pyrimidin-4-one
• CAS: 881917-70-0
• 化学式: C₂₃H₂₂FN₇O
• 分子量: 431.472
• InChiKey: HCBYUZWOALMXKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  79.5
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• US8129377B2
  申请人：——

  公开号：US8129377B2

  公开（公告）日：2012-03-06
• [EN] PYRIMIDONE COMPOUND<br/>[FR] COMPOSE PYRIMIDONE
  申请人：MITSUBISHI PHARMA CORP

  公开号：WO2006036015A2

  公开（公告）日：2006-04-06

  A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof:wherein R1 represents a C1-C12 alkyl; R2 represents a hydrogen atom or the like; R3 represents a halogen or the like; q represents an integer of 1 to 7; R4 represents a halogen or the like; p represents 0 or an integer of 1 to 5; R5 represents a C6-C10 aryl, a heterocycle or the like; and X represents oxygen, NH, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).