3-methoxy-4-[2-[2-methoxy-4-[[[6-(4-methoxyphenyl)-4-[(2-methoxyphenyl)methyl]pyridazin-3-yl]hydrazinylidene]methyl]phenoxy]ethoxy]benzaldehyde | 1155315-06-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-methoxy-4-[2-[2-methoxy-4-[[[6-(4-methoxyphenyl)-4-[(2-methoxyphenyl)methyl]pyridazin-3-yl]hydrazinylidene]methyl]phenoxy]ethoxy]benzaldehyde
• CAS: 1155315-06-2
• 化学式: C₃₇H₃₆N₄O₇
• 分子量: 648.715
• InChiKey: JPXWQZXPWIFJNE-UHFFFAOYSA-N

物化性质

• 熔点：
  215-217 °C(Solvent: Dimethylformamide)
• 沸点：
  833.3±65.0 °C(predicted)
• 密度：
  1.21±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.91
• 重原子数：
  48.0
• 可旋转键数：
  15.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  125.85
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为产物：
  描述：

  、 4,4′-[ethane-1,2-diylbis(oxy)]bis(3-methoxy-benzaldehyde) 以 乙醇 为溶剂， 反应 5.0h， 以60%的产率得到3-methoxy-4-[2-[2-methoxy-4-[[[6-(4-methoxyphenyl)-4-[(2-methoxyphenyl)methyl]pyridazin-3-yl]hydrazinylidene]methyl]phenoxy]ethoxy]benzaldehyde
  参考文献：
  名称：

  Novel pyridazine derivatives: Synthesis and antimicrobial activity evaluation

  摘要：

  A general method for the preparation of new hydrazones is reported. The 1-[4-(2-methoxybenzyl)-6-aryl pyridazin-3(2H)-ylidene] hydrazines or their tautomeric structures (1(a-d)) were condensed with different aldehydes, dialdehydes, ketones, alpha-dicarbonyl compounds and simple carbohydrates to afford the hydrazones and dihydrazones (2(a-d)), (3(a-d)), (4(a-d)), (5(a-d)), (6(d)). (7(c)), (8(a-d)), (9(a-d)), (10(a-d)), (11(a-d)), (12(a,c,d)), (13(a-d)), (14(a-d)). (15(a-d)), (16(a-d)) and (17(a-d)). The structures of all synthesized compounds were confirmed from microanalytical and spectral data. Some of the products were screened for their antimicrobial activity against Staphylococcus aureus and Streptococcus faecalis, Escherichia coli and Pseudomonas aeruginosa. The hydrazone derivative 15(d) (1-[4-(2-methoxybenzyl)-6-methylphenyl pyridazin-3(2H)-ylidene]-2-(2-carboxydiphenyl methyl) hydrazine) showed the highest biological activity. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.09.047