N-Cbz-L-seryl-L-leucyl-L-alaninamide | 167776-08-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Cbz-L-seryl-L-leucyl-L-alaninamide
• CAS: 167776-08-1
• 化学式: C₂₀H₃₀N₄O₆
• 分子量: 422.481
• InChiKey: MBYSERAJJBGXGM-BPUTZDHNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.21
• 重原子数：
  30.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  159.85
• 氢给体数：
  5.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  甲酸 、 N-Cbz-L-seryl-L-leucyl-L-alaninamide 在 palladium/alumina 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 L-seryl-L-leucyl-L-alaninamide formate salt
  参考文献：
  名称：

  Enzymic Synthesis of the Delicious Peptide Fragments in Eutectic Mixtures

  摘要：

  The feasibility of flavor peptide production has been investigated using proteases in liquid/semiliquid eutectic mixtures comprised of the substrates together with small amounts of water and alcohols (19-24% w/w). The three functional fragments of the so-called ''Delicious Octapeptide'', L-Lys-Gly, L-Asp-Glu-Glu, and L-Ser-Leu-Ala, were obtained in good yields without any requirement for the regioselective side-chain protection of multifunctional amino acids. The peptides were synthesized on a preparative scale in overall yields of 29-77% and were fully characterized.

  DOI：

  10.1021/jf00057a040
• 作为产物：
  描述：

  L-亮氨酸乙酯 在 N,N-二异丙基乙胺 作用下， 以 水 、 甘油 为溶剂， 反应 64.0h， 生成 N-Cbz-L-seryl-L-leucyl-L-alaninamide
  参考文献：
  名称：

  Enzymic Synthesis of the Delicious Peptide Fragments in Eutectic Mixtures

  摘要：

  The feasibility of flavor peptide production has been investigated using proteases in liquid/semiliquid eutectic mixtures comprised of the substrates together with small amounts of water and alcohols (19-24% w/w). The three functional fragments of the so-called ''Delicious Octapeptide'', L-Lys-Gly, L-Asp-Glu-Glu, and L-Ser-Leu-Ala, were obtained in good yields without any requirement for the regioselective side-chain protection of multifunctional amino acids. The peptides were synthesized on a preparative scale in overall yields of 29-77% and were fully characterized.

  DOI：

  10.1021/jf00057a040