1-morpholino-[2-O-(2'-methoxyethoxymethyl)-3,4:5,6-di-O-isopropylidene]-D-gluconamide | 1192301-60-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-morpholino-[2-O-(2'-methoxyethoxymethyl)-3,4:5,6-di-O-isopropylidene]-D-gluconamide
• CAS: 1192301-60-2
• 化学式: C₂₀H₃₅NO₉
• 分子量: 433.499
• InChiKey: OXMMLYUBDFUAPI-WCXIOVBPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.52
• 重原子数：
  30.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  94.15
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  1-morpholino-[2-O-(2'-methoxyethoxymethyl)-3,4:5,6-di-O-isopropylidene]-D-gluconamide 在 sodium tetrahydroborate 、 水 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以82%的产率得到2-O-(2'-methoxyethoxymethyl)-3,4:5,6-di-O-isopropylidene-D-glucitol
  参考文献：
  名称：

  2-O-Benzylation in D-Gluconamide Derivative Under Basic Conditions with Complete Retention of Stereo-Integrity: Convenient Access to 2-O-benzyl-3,4:5,6- di-O-isopropylidene-D-glucitol and other Differently Protected D-glucitol Derivatives

  摘要：

  A new and convenient synthesis of 2-O-benzyl-3,4:5,6-di-O-isopropylidene-D-glucitol has been accomplished and has been generalized with the syntheses of differently protected D-glucitols at C-2 position. In the course of our new route to the differently protected D-glucitols at C-2 position, a new D-gluco configured building block, 1-morpholino-(3,4:5,6-di-O-isopropylidene)-D-gluconamide has been achieved.

  DOI：

  10.1080/07328300902979503
• 作为产物：
  描述：

  2-甲氧基乙氧基甲基氯 、 1-morpholino-(3,4:5,6-di-O-isopropylidene)-D-gluconamide 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以90%的产率得到1-morpholino-[2-O-(2'-methoxyethoxymethyl)-3,4:5,6-di-O-isopropylidene]-D-gluconamide
  参考文献：
  名称：

  2-O-Benzylation in D-Gluconamide Derivative Under Basic Conditions with Complete Retention of Stereo-Integrity: Convenient Access to 2-O-benzyl-3,4:5,6- di-O-isopropylidene-D-glucitol and other Differently Protected D-glucitol Derivatives

  摘要：

  A new and convenient synthesis of 2-O-benzyl-3,4:5,6-di-O-isopropylidene-D-glucitol has been accomplished and has been generalized with the syntheses of differently protected D-glucitols at C-2 position. In the course of our new route to the differently protected D-glucitols at C-2 position, a new D-gluco configured building block, 1-morpholino-(3,4:5,6-di-O-isopropylidene)-D-gluconamide has been achieved.

  DOI：

  10.1080/07328300902979503