| 1369558-62-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1369558-62-2
• 化学式: C₂₃H₄₄O₄
• 分子量: 384.6
• InChiKey: OXPGJXNOESRJJL-RTWAWAEBSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以88%的产率得到(S)-5-((1R)-1-hydroxytetradecyl)-dihydrofuran-2(3H)-one
  参考文献：
  名称：

  Asymmetric Synthesis of (-)-Muricatacin’s Analogue (4S,5R)-5-Hydroxy-4-octadecanolide Exhibiting the Cytotoxicity against Esphageal Cancer Cells

  摘要：

  An efficient and facile synthesis, in six steps and 50% overall yield from commercial D-(-)-lyxose as starting material via twice Wittig olefination and one-pot deisopropylidenation and intramolecular lactonization, of the enantiopure (4S,5R)-(+)-5-hydroxy-4-octadecanolide (2), analogue of (-)-muricatacin, and the cytotoxic activity against CE48T cell line (human esophageal carcinoma) are described and the biological activity is the first shown in the literature.

  DOI：

  10.3987/com-11-12397
• 作为产物：
  描述：

  在 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以99%的产率得到
  参考文献：
  名称：

  Asymmetric Synthesis of (-)-Muricatacin’s Analogue (4S,5R)-5-Hydroxy-4-octadecanolide Exhibiting the Cytotoxicity against Esphageal Cancer Cells

  摘要：

  An efficient and facile synthesis, in six steps and 50% overall yield from commercial D-(-)-lyxose as starting material via twice Wittig olefination and one-pot deisopropylidenation and intramolecular lactonization, of the enantiopure (4S,5R)-(+)-5-hydroxy-4-octadecanolide (2), analogue of (-)-muricatacin, and the cytotoxic activity against CE48T cell line (human esophageal carcinoma) are described and the biological activity is the first shown in the literature.

  DOI：

  10.3987/com-11-12397