tert-butyl [4-(1-pyrenoylamino)butyl]carbamate | 1036202-44-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: tert-butyl [4-(1-pyrenoylamino)butyl]carbamate
• CAS: 1036202-44-4
• 化学式: C₂₆H₂₈N₂O₃
• 分子量: 416.52
• InChiKey: STBTVRQHMIXZPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.62
• 重原子数：
  31.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  67.43
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  tert-butyl [4-(1-pyrenoylamino)butyl]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  A novel pyrene-guanidiniocarbonyl-pyrrole cation efficiently differentiates between ds-DNA and ds-RNA by two independent, sensitive spectroscopic methods

  摘要：

  At micromolar concentrations and equimolar conditions in respect to basepairs, a novel pyrene-guanidiniocarbonyl-pyrrole cation 1 exhibited a strong ICD signal at about lambda = 300 nm specifically upon the interaction with ds-DNA, while under the same conditions a new fluorescence maximum at lambda = 480 nm appeared exclusively upon the addition of ds-RNA. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.03.060
• 作为产物：
  描述：

  N-叔丁氧羰基-1,4-丁二胺 、 1-芘甲酸 在 N-甲基吗啉 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以93%的产率得到tert-butyl [4-(1-pyrenoylamino)butyl]carbamate
  参考文献：
  名称：

  A novel pyrene-guanidiniocarbonyl-pyrrole cation efficiently differentiates between ds-DNA and ds-RNA by two independent, sensitive spectroscopic methods

  摘要：

  At micromolar concentrations and equimolar conditions in respect to basepairs, a novel pyrene-guanidiniocarbonyl-pyrrole cation 1 exhibited a strong ICD signal at about lambda = 300 nm specifically upon the interaction with ds-DNA, while under the same conditions a new fluorescence maximum at lambda = 480 nm appeared exclusively upon the addition of ds-RNA. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.03.060