3-[2-(4-difluoromethoxy-3-hydroxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one | 937781-80-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[2-(4-difluoromethoxy-3-hydroxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one
• 英文别名: 3-[2-[4-(difluoromethoxy)-3-hydroxyphenyl]-1,3-oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one
• CAS: 937781-80-1
• 化学式: C₁₉H₁₆F₂N₂O₄
• 分子量: 374.344
• InChiKey: XUXPJDGVWAHJGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  85.4
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3-[2-(4-difluoromethoxy-3-hydroxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one 、 碘乙烷 以white powdery 3-[2-(4-difluoromethoxy-3-ethoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one was obtained的产率得到3-[2-(4-Difluoromethoxy-3-ethoxyphenyl)oxazol-4-yl]-1-(3-methylpyridin-2-yl)propan-1-one
  参考文献：
  名称：

  OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION

  摘要：

  本发明提供了一种由公式（1）表示的噁唑化合物或其盐：其中，R1是一个芳基基团，可以具有一个或多个取代基；R2是一个芳基基团或含有氮原子的杂环基团，每个基团都可以具有一个或多个取代基；W是一个由—Y1-A1-或—Y2—C（═O）—表示的二价基团，其中Y1是例如—C（═O）—的基团，A1是例如低碳链基团的基团，而Y2是例如哌嗪二基基团的基团。该噁唑化合物具有特定的磷酸二酯酶4的抑制作用。

  公开号：

  US20090221586A1

文献信息

• [EN] METHOD FOR PRODUCING OXAZOLE COMPOUND<br/>[FR] PROCÉDÉ DE PRODUCTION DE COMPOSÉ OXAZOLE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2014034958A1

  公开（公告）日：2014-03-06

  An object of the present invention is to provide a novel method for producing an oxazole compound. The invention relates to a method for producing a compound represented by formula (1): wherein R1 is lower alkyl group or halogen substituted lower alkyl group, R2 is lower alkyl group, R5 is lower alkyl group, R11 is lower alkyl group, halogen substituted lower alkyl group or a group represented by formula: -CY2COOR12, wherein Y is a halogen atom, R12 is an alkali metal atom or lower alkyl group, Ar1 is phenyl group substituted with lower alkyl group, etc., or pyridyl group substituted with lower alkyl group, etc., X2, X3 and X9 are the same or different and are halogen atoms, X4 is a leaving group, and M is an alkali metal atom.

  本发明的目的是提供一种生产噁唑化合物的新方法。该发明涉及一种生产由式（1）表示的化合物的方法：其中R1是较低的烷基或卤素取代的较低烷基，R2是较低的烷基，R5是较低的烷基，R11是较低的烷基，卤素取代的较低烷基或由式表示的基团：-CY2COOR12，其中Y是卤素原子，R12是碱金属原子或较低的烷基，Ar1是苯基取代的较低烷基等，或吡啶基取代的较低烷基等，X2、X3和X9相同或不同，是卤素原子，X4是一个离去基团，M是一种碱金属原子。
• Method for Producing Oxazole Compound
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US20150239855A1

  公开（公告）日：2015-08-27

  An object of the present invention is to provide a novel method for producing an oxazole compound. The invention relates to a method for producing a compound represented by formula (1): wherein R 1 is lower alkyl group or halogen substituted lower alkyl group, R 2 is lower alkyl group, R 5 is lower alkyl group, R 11 is lower alkyl group, halogen substituted lower alkyl group or a group represented by formula: —CY 2 COOR 12 , wherein Y is a halogen atom, R 12 is an alkali metal atom or lower alkyl group, Ar 1 is phenyl group substituted with lower alkyl group, etc., or pyridyl group substituted with lower alkyl group, etc., X 2 , X 3 and X 9 are the same or different and are halogen atoms, X 4 is a leaving group, and M is an alkali metal atom.

  本发明的目的是提供一种生产噁唑化合物的新方法。本发明涉及一种生产由式（1）表示的化合物的方法：其中R1是较低的烷基或卤代较低的烷基，R2是较低的烷基，R5是较低的烷基，R11是较低的烷基，卤代较低的烷基或由式子表示的基团：—CY2COOR12，其中Y是卤素原子，R12是碱金属原子或较低的烷基，Ar1是苯基，其上取代有较低的烷基等，或吡啶基，其上取代有较低的烷基等，X2、X3和X9相同或不同，均为卤素原子，X4是离去基团，M是碱金属原子。
• Oxazole compound and pharmaceutical composition
  申请人：Okada Minoru

  公开号：US08637559B2

  公开（公告）日：2014-01-28

  The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R1 is an aryl group which may have one or more substituents; R2 is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by —Y1-A1- or —Y2—C(═O)— wherein Y1 is a group such as —C(═O)—, A1 is a group such as a lower alkylene group, and Y2 is a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

  本发明提供一种由式（1）表示的噁唑酮化合物或其盐： 其中，R1是一个芳基基团，可能具有一个或多个取代基；R2是一个芳基基团或氮原子含量的杂环基团，每个基团可能具有一个或多个取代基；W是一个由—Y1-A1-或—Y2—C(═O)—表示的二价基团，其中Y1是如—C(═O)—这样的基团，A1是如较低的烷基链这样的基团，Y2是如哌嗪二基基团这样的基团。该噁唑酮化合物对磷酸二酯酶4具有特定的抑制作用。
• EP1954684B1
  申请人：——

  公开号：EP1954684B1

  公开（公告）日：2014-05-07
• METHOD FOR PRODUCING OXAZOLE COMPOUND
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP2890686B1

  公开（公告）日：2017-01-04