2,2-dimethyl-7-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-5-oxo-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyridine-8-carbonitrile | 1393330-93-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,2-dimethyl-7-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-5-oxo-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyridine-8-carbonitrile
• CAS: 1393330-93-2
• 化学式: C₂₄H₂₅N₃O₃S
• 分子量: 435.547
• InChiKey: QRPQAJBMWPWLCQ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  甲氧苯胺 、 异丁醛 、 N-methylmorpholinium 5-cyano-4-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolate 以 乙醇 为溶剂， 以26%的产率得到2,2-dimethyl-7-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-5-oxo-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyridine-8-carbonitrile
  参考文献：
  名称：

  Mannich reaction in the synthesis of N,S-containing heterocycles. 14*. Unexpected formation of thiazolo[3,2-a]pyridines in the aminoalkylation of N-methylmorpholinium 4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates by isobutyraldehyde and primary amines

  摘要：

  Treatment of N-methylmorpholinium 4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates with an excess of isobutyraldehyde and primary aromatic amines in refluxing ethanol gives the corresponding 7-aryl-3-arylamino-2,2-dimethyl-5-oxo-2,3,6,7-tetrahydro-5 H-thiazolo[3,2-a]pyridine-8-carbonitriles in 18-38 % yields.

  DOI：

  10.1007/s10593-012-1042-y