1-(3,5-difluoro-4-hydroxyphenyl)-5-(3,5-dimethylisoxazol-4-yl)-3-ethyl-N'-hydroxy-1H-pyrazole-4-carboximidamide | 1290138-01-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(3,5-difluoro-4-hydroxyphenyl)-5-(3,5-dimethylisoxazol-4-yl)-3-ethyl-N'-hydroxy-1H-pyrazole-4-carboximidamide
• 英文别名: 1-(3,5-difluoro-4-hydroxyphenyl)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-3-ethyl-N'-hydroxypyrazole-4-carboximidamide
• CAS: 1290138-01-0
• 化学式: C₁₇H₁₇F₂N₅O₃
• 分子量: 377.35
• InChiKey: JCPAKOHXGCSEFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS
  申请人：Löfstedt Joakim

  公开号：US20120202853A1

  公开（公告）日：2012-08-09

  The invention provides a compound of formula (I) wherein G is a pyrazole ring as defined in the specification and R 4 , R 5 , R 6 and R 7 are as defined in the specification; or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.

  该发明提供了一个式（I）的化合物，其中G是规范中定义的吡唑环，R4、R5、R6和R7如规范中定义；或其药学上可接受的酯、酰胺、溶剂合物或盐，包括这种酯或酰胺的盐，以及这种酯、酰胺或盐的溶剂合物。该发明还提供了这些化合物在治疗或预防与雌激素受体活性相关的疾病或紊乱相关的病症的用途。
• Estrogen receptor ligand treatment for neurodegenerative diseases
  申请人：The Regents of the University of California

  公开号：US10758496B2

  公开（公告）日：2020-09-01

  The present invention relates to treatment of neurological diseases such as multiple sclerosis (MS) and Alzheimer's disease, using an estrogen receptor beta (ERβ) ligand.

  本发明涉及使用雌激素受体β（ERβ）配体治疗神经系统疾病，如多发性硬化症（MS）和阿尔茨海默病。
• ESTROGEN RECEPTOR LIGAND TREATMENT FOR NEURODEGENERATIVE DISEASES
  申请人：The Regents of the University of California

  公开号：EP3189026B1

  公开（公告）日：2020-07-22
• US8653112B2
  申请人：——

  公开号：US8653112B2

  公开（公告）日：2014-02-18
• US8921402B2
  申请人：——

  公开号：US8921402B2

  公开（公告）日：2014-12-30