1-o-Chlorbenzyl-5-ethyl-4-phenyl-2-thioimidazol | 32273-22-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-o-Chlorbenzyl-5-ethyl-4-phenyl-2-thioimidazol
• 英文别名: 3-[(2-chlorophenyl)methyl]-4-ethyl-5-phenyl-1H-imidazole-2-thione
• CAS: 32273-22-6
• 化学式: C₁₈H₁₇ClN₂S
• 分子量: 328.865
• InChiKey: JSNXNFWFIQIXKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  47.4
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Mercaptoimidazoles as Ccr2 Receptor Antagonists
  申请人：Boeckx Maria Gustaaf

  公开号：US20070249691A1

  公开（公告）日：2007-10-25

  The present invention relates to a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine, a polymorphic form or a stereochemically isomeric form thereof, wherein R 1 represents hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkyloxyC 1-6 alkyl, di(C 1-6 alkyl)aminoC 1-6 alkyl, aryl or heteroaryl; each R 2 independently represents halo, C 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkylthio, polyhaloC 1-6 alkyl, polyhaloC 1-6 alkyloxy, cyano, aminocarbonyl, amino, mono- or di(C 1-4 alkyl)amino, nitro, aryl or aryloxy; R 3 represents hydrogen, cyano, optionally substituted C 1-6 alkyl, C(═O)—O—R 5 , C(═O)—NR 6a R 6b , C(═S)—NR 6a R 6b , S(═O) 2 —NR 6a R 6b or C(═O)—R 7 ; R 4 represents hydrogen or C 1-6 alkyl; n is 1, 2, 3, 4 or 5; Z represents a cyclic ring system. The invention also relates to processes for preparing the compounds of formula (I), their use as CCR2 antagonists and pharmaceutical compositions comprising them.