dithiobis(succinimidylundecanoate) | 147072-47-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dithiobis(succinimidylundecanoate)
• 英文别名: 2,5-Pyrrolidinedione, 1,1'-[dithiobis[(1-oxo-11,1-undecanediyl)oxy]]bis-；(2,5-dioxopyrrolidin-1-yl) 11-[[11-(2,5-dioxopyrrolidin-1-yl)oxy-11-oxoundecyl]disulfanyl]undecanoate
• CAS: 147072-47-7
• 化学式: C₃₀H₄₈N₂O₈S₂
• 分子量: 628.852
• InChiKey: JOKQWUXBBOQYTJ-UHFFFAOYSA-N

物化性质

• 沸点：
  705.9±70.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  42
• 可旋转键数：
  27
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  178
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  dithiobis(succinimidylundecanoate) 、 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以546 mg的产率得到3-[{6-[11-(10-{6-[Bis-(2-methoxycarbonyl-ethyl)-amino]-hexylcarbamoyl}-decyldisulfanyl)-undecanoylamino]-hexyl}-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester
  参考文献：
  名称：

  Surfaces Designed for Charge Reversal

  摘要：

  We have created surfaces which switch from cationic at pH < 3 to anionic at pH > 5, by attaching aminodicarboxylic acid units to silica and gold substrates. Charge reversal was demonstrated by monitoring the adsorption of cationic dyes (methylene blue and a tetracationic porphyrin) and an anionic sulfonated porphyrin, at a range of pH using UV-vis absorption and reflection spectroscopy. The cationic dyes bind under neutral conditions (pH 5-7) and are released at pH 1-4, whereas the anionic dye binds under acidic conditions (pH 1-4) and is released at pH 5-7. Gold surfaces were functionalized with two different amphoteric disulfides with short (CH2)(2) and long (CH2)(10)CONH(CH2)(6) linkers; the longer disulfide gave surfaces exhibiting charge reversal in a narrower pH range. Adsorption is much faster on the functionalized gold (t(1/2) = 62 s) than on functionalized silica (t(1/2) = 6900 s), but the final extents of coverage on both surface are similar, for a given dye at a given pH, with maximal coverages of around 2 molecules nm(-2). These charge-reversal processes are reversible and can be repeatedly cycled by changing the pH. We have also created surfaces which undergo irreversible proton-triggered charge switching, using a carbamate-linked thiol carboxylic acid which cleaves in acid. These surfaces are versatile new tools for controlling electrostatic self-assembly at surfaces.

  DOI：

  10.1021/ja028338b
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 11,11'-disulfanediyldiundecanoyl chloride 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 dithiobis(succinimidylundecanoate)
  参考文献：
  名称：

  N-sulfonylaminocarbonyl containing compounds

  摘要：

  描述了具有两个反应性功能基团的化合物，可用于在基底和含胺材料之间提供连接器基团。第一个反应性功能基团可用于与基底表面结合。第二个反应性功能基团是N-磺酰氨基甲酰基团，可与含胺材料，特别是一次脂肪族胺反应，形成含有羰基亚胺的连接器基团。该发明还提供了用于将含胺材料固定到基底的物品和方法。

  公开号：

  US20050107615A1

文献信息

• METHOD FOR INTRODUCING FUNCTIONAL GROUP TO SURFACE OF MATERIAL
  申请人：Kangnung-Wonju National University Industry Academy Cooperation Group

  公开号：EP2354146A1

  公开（公告）日：2011-08-10

  The present invention relates to a method for introducing a functional group to the surface of a material. The present invention provides a method for introducing a mixture of a lipid and a compound containing a functional group to the surface of a material. The method, for example, comprises the steps of: mixing a lipid with a compound containing a functional group to form liposome; and introducing the liposome to the surface of a material. The method enables a simple process and the reduction of processing time, compared with conventional chemical surface treatment methods. Additionally, the method ensures high efficiency and reproducibility when fixing a receptor on the surface of a material. Furthermore, the method does not need to use various reagents and is simple, so people unfamiliar with chemistry can utilize the method easily.

  本发明涉及一种将官能团引入材料表面的方法。本发明提供了一种将脂质和含有官能团的化合物的混合物引入材料表面的方法。例如，该方法包括以下步骤：将脂质与含有官能团的化合物混合形成脂质体；以及将脂质体引入材料表面。与传统的化学表面处理方法相比，该方法工艺简单，可缩短处理时间。此外，该方法还能确保在材料表面固定受体时的高效率和可重复性。此外，该方法无需使用各种试剂，操作简单，不熟悉化学的人也能轻松使用。
• ENZYME ELECTRODE AND BIOSENSOR USING THE SAME
  申请人：ARKRAY, Inc.

  公开号：EP3249050A1

  公开（公告）日：2017-11-29

  An enzyme electrode comprising; an electrode comprising a current collector; a monolayer-forming molecule bound to the surface of the current collector; and glucose dehydrogenase comprising a cytochrome C subunit bound to the monolayer-forming molecule; wherein electrons are transferred between the glucose dehydrogenase and the current collector by an oxidation-reduction reaction of the glucose dehydrogenase.

  一种酶电极，包括：一个由集流器组成的电极； 与集流器表面结合的单层形成分子；以及由与单层形成分子结合的细胞色素 C 亚基组成的葡萄糖脱氢酶；其中电子通过葡萄糖脱氢酶的氧化还原反应在葡萄糖脱氢酶和集流器之间转移。
• SEMICONDUCTOR SENSOR AND MANUFACTURING METHOD FOR SAME, AND COMPOUND SENSOR
  申请人：Toray Industries, Inc.

  公开号：EP3531131A1

  公开（公告）日：2019-08-28

  In order to selectively detect a target substance in high sensitivity, a semiconductor sensor includes a substrate, a first electrode, a second electrode, and a semiconductor layer located between the first electrode and the second electrode, in which the semiconductor layer includes a semiconducting component and a substructure of immunoglobulin, and the substructure of immunoglobulin is bonded or attached to the semiconducting component through a linking group L1 in a hinge region of a heavy chain. Moreover, a method for producing a semiconductor sensor includes a step of forming the semiconductor layer, the step including a step of applying a semiconducting component between the first electrode and the second electrode.

  为了高灵敏度地选择性检测目标物质，一种半导体传感器包括基板、第一电极、第二电极和位于第一电极和第二电极之间的半导体层，其中半导体层包括半导体元件和免疫球蛋白的子结构，免疫球蛋白的子结构通过重链铰链区中的连接基L1键合或连接到半导体元件上。此外，一种生产半导体传感器的方法包括形成半导体层的步骤，该步骤包括在第一电极和第二电极之间施加半导体成分的步骤。
• Method for highly sensitive detection of biomarkers for diagnostics
  申请人：The Trustees of Princeton University

  公开号：US10234394B2

  公开（公告）日：2019-03-19

  This disclosure provides, among other things, a nanosensor comprising a substrate and one or a plurality of pillars extending from a surface of the substrate, where the pillars comprise a metallic dot structure, a metal disc, and a metallic back plane. The nanosensor comprises a molecular adhesion layer that covers at least a part of the metallic dot structure, the metal disc, and/or the metallic back plane and a capture agent bound to the molecular adhesion layer. The nanosensor amplifies a light signal from an analyte, when the analyte is specifically bound to the capture agent.

  本公开提供了一种纳米传感器，包括基底和从基底表面延伸的一个或多个支柱，其中支柱包括金属点结构、金属圆盘和金属背平面。纳米传感器包括覆盖金属点结构、金属盘和/或金属背平面至少一部分的分子粘附层，以及与分子粘附层结合的捕获剂。当被分析物与捕获剂特异性结合时，纳米传感器会放大来自被分析物的光信号。
• Use of immobilization particles for removal of microorganisms and/or chemicals
  申请人：NuBiome, Inc.

  公开号：US10245279B2

  公开（公告）日：2019-04-02

  Method for immobilizing a target microorganism or target chemical found in a mammal includes introducing into a gastrointestinal tract of the mammal immobilization particles including immobilization molecules capable of attaching to the target microorganism or the target chemical, which immobilization molecules are attached to one or more portions of a structure that is capable of inhibiting contact between tissues of the gastrointestinal tract and the target microorganisms or target chemicals attached to the immobilization molecules.

  固定哺乳动物体内发现的目标微生物或目标化学品的方法包括将固定颗粒引入哺乳动物的胃肠道，固定颗粒包括能够附着在目标微生物或目标化学品上的固定分子，这些固定分子附着在一个结构的一个或多个部分上，该结构能够抑制胃肠道组织与附着在固定分子上的目标微生物或目标化学品之间的接触。