硬脂酰酪氨酸盐酸盐 | 77229-76-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 硬脂酰酪氨酸盐酸盐
• 英文名称: stearyl tyrosine hydrochloride
• 英文别名: (S)-octadecyl 2-amino-3-(4-hydroxyphenyl)propanoate hydrochloride；octadecyl (2S)-2-amino-3-(4-hydroxyphenyl)propanoate;hydrochloride
• CAS: 77229-76-6
• 化学式: C₂₇H₄₇NO₃*ClH
• 分子量: 470.136
• InChiKey: DSNORQKTMHLZGV-SNYZSRNZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.49
• 重原子数：
  32
• 可旋转键数：
  21
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  72.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硬脂醇 、 L-酪氨酸 在 盐酸 、 甲烷磺酸 作用下， 反应 2.5h， 以90%的产率得到硬脂酰酪氨酸盐酸盐
  参考文献：
  名称：

  A simple method for the synthesis of long-chain alkyl esters of amino acids

  摘要：

  DOI：

  10.1021/jo00209a018

文献信息

• Synthetic adjuvants for stimulating antigenic responses
  申请人：CONNAUGHT LABORATORIES LIMITED

  公开号：EP0018189A2

  公开（公告）日：1980-10-29

  An antigen composition such as tetanus toxoid or polyomyelitis vaccine having an improved efficacy over the plain antigen comprises at least one bacterial or viral antigenic species and at least one adjuvant in an amount effective to enhance the antigenic response of the antigenic species; the adjuvant is an ester of a long chain alcohol containing 10 to 22 carbon atoms and an amino acid, for example octadecyl tyrosine.

  一种抗原组合物，如破伤风类毒素疫苗或多发性骨髓炎疫苗，与普通抗原相比具有更好的功效，它包括至少一种细菌或病毒抗原种类和至少一种佐剂，佐剂的用量可有效增强抗原种类的抗原反应；佐剂是含有 10 至 22 个碳原子的长链醇和氨基酸（如十八烷基酪氨酸）的酯。
• Neisseria meningitidis capsular polysaccharide conjugates
  申请人：CONNAUGHT LABORATORIES LIMITED

  公开号：EP0747063A2

  公开（公告）日：1996-12-11

  Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant reactive residues of heterobifunctional linker molecules to the polysaccharide backbone. The capsular polysaccharide is deacetylated and the heterobifunctional linker molecule is reacted with the deacetylated material and any residual amino groups are blocked by reaction with alkyl acid anhydride. The introduction of the linker molecules to the polysaccharide chain between the termini enables the polysaccharide to be linked to a carrier molecule, such as a protein, to enhance the immunogenicity of the polysaccharide. The conjugate molecule may be formulated as an immunogenic composition for raising antibodies in a host to the polysaccharide.

  通过化学反应对含有多个硅铝酸残基的胶囊多糖，特别是脑膜炎奈瑟氏菌的 B 组多糖进行修饰，在多糖骨架上随机引入杂双官能团连接分子的悬垂反应残基。胶囊多糖经过脱乙酰化处理，杂多官能团连接分子与脱乙酰化材料发生反应，任何残留的氨基基团通过与烷基酸酐反应被阻断。将连接分子引入多糖链的端部之间，可使多糖与蛋白质等载体分子连接，从而增强多糖的免疫原性。共轭分子可配制成免疫原性组合物，用于在宿主体内产生针对多糖的抗体。
• Acellular pertussis vaccines and methods of preparation thereof
  申请人：Aventis Pasteur Limited

  公开号：EP1233022A1

  公开（公告）日：2002-08-21

  A fimbrial agglutinogen preparation is prepared from a Bordetella strain, particularly a B.pertussis strain, by a multiple step procedure involving extraction of the fimbrial agglutinogens from cell paste and concentrating and purifying the extracted material. The fimbrial agglutinogen preparation may be used to prepare acellular pertussis vaccines with other pertussis antigens, including pertussis toxin or toxoid thereof, the 69 kDa protein and filamentous haemagglutonin and other Bordetella antigens. Such vaccines confer protection to at least 70% of an at-risk human population.

  从百日咳杆菌菌株（尤其是百日咳杆菌菌株）中制备流脑凝集素原制剂的步骤很多，包括从细胞糊中提取流脑凝集素原，浓缩和纯化提取物。流苏凝集素原制剂可用于制备含有其他百日咳抗原的无细胞百日咳疫苗，包括百日咳毒素或其类毒素、69 kDa 蛋白和丝状血凝素以及其他博德特氏菌抗原。此类疫苗可为至少 70% 的高危人群提供保护。
• Acellular Pertussis Vaccines and Methods of Preparation Thereof
  申请人：Aventis Pasteur Limited

  公开号：EP1234579A1

  公开（公告）日：2002-08-28

  Acellular pertussis vaccines comprise purified toxin or toxoid thereof, filamentous haemagglutinin, pertactin and fimbrial agglutinogens formulated to confer protection to at least 70% of members of an at-risk population. The fimbrial agglutinogens may be prepared from a Bordetella strain, particularly a B.pertussis strain, by a multiple step procedure involving extraction of the fimbrial agglutinogens from cell paste and concentrating and purifying the extracted material.

  细胞百日咳疫苗由纯化的毒素或其类毒素、丝状血凝素、百日咳凝集素和缘膜凝集素原组成，配制成的疫苗可为至少 70% 的高危人群提供保护。可从博德特氏菌菌株，特别是百日咳杆菌菌株中制备丝状凝集素，制备过程分为多个步骤，包括从细胞糊中提取丝状凝集素，浓缩和纯化提取物。
• Modified CEA and uses thereof
  申请人：Aventis Pasteur Limited

  公开号：EP1561817A2

  公开（公告）日：2005-08-10

  The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.

  本发明公开了具有免疫原性的 CEA 激动剂多肽/蛋白，其包含含有 YLSGADLNL 氨基酸序列的修饰表位、编码该表位的核酸、包含上述核酸的载体和/或细胞，以及其混合物和/或组合物。还公开了利用上述制剂激发或诱导 CEA 特异性免疫反应的方法。