2-[(5-nitro-thiazol-2-yl)mercapto]-5-t-butyl-1,2,4-triazole | 1099458-79-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[(5-nitro-thiazol-2-yl)mercapto]-5-t-butyl-1,2,4-triazole
• 英文别名: 2-[(3-Tert-butyl-1,2,4-triazol-1-yl)sulfanyl]-5-nitro-1,3-thiazole
• CAS: 1099458-79-3
• 化学式: C₉H₁₁N₅O₂S₂
• 分子量: 285.351
• InChiKey: CGSDKQFMCUYBSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  143
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Formulations for hydrophobic pharmaceutical agents
  申请人：——

  公开号：US20010012844A1

  公开（公告）日：2001-08-09

  The present invention features formulations, including liquid, semi-solid or solid pharmaceutical formulations, that improve the oral bioavailability of hydrophobic pharmaceutical agents, such as quinazoline-, nitrothiazole-, and indolinone-based compounds. Also featured are formulations for parenteral delivery of such hydrophobic pharmaceutical agents, as well as methods of making and using both types of formulations.

  本发明涉及包括液体、半固体或固体制剂的配方，可以提高疏水性药物，如喹唑啉、硝基噻唑和吲哚酮类化合物的口服生物利用度。还包括适用于静脉注射递送这些疏水性药物的配方，以及制备和使用这两种类型配方的方法。
• Cancer treatment with Go6976 and its related compounds
  申请人：——

  公开号：US20020016352A1

  公开（公告）日：2002-02-07

  A chemotheraputic cancer treatment in which Gö6976 or a compound chemically similar to Gö6976 is administered to a mammal for the treatment of the cancer. The chemical compound is targeted to PKC &agr; activity. Experiments have shown Gö6976 and similar compounds to be effective for the treatment of breast cancer, leukemia, lung cancer, bone cancer, skin cancer, prostate cancer, liver cancer, brain tumor, cervical cancer, and cancers located in the digestive tract including gastric cancer and colorectal cancers. These treatments may be accomplished utilizing Gö6976 and compounds similar to it alone or in combination with prior art chemotherapy agents or with radiation therapy. In a preferred embodiment Gö6976 is used for the treatment of cancer as a preventative drug by preventing cancer cell formation.

  一种癌症化疗方法，将 Gö6976 或与 Gö6976 化学性质相似的化合物施用到哺乳动物体内以治疗癌症。该化合物以 PKC &agr; 活性为靶点。实验表明，Gö6976 和类似化合物可有效治疗乳腺癌、白血病、肺癌、骨癌、皮肤癌、前列腺癌、肝癌、脑瘤、宫颈癌和消化道癌症，包括胃癌和结肠直肠癌。这些治疗可以单独使用 Gö6976 及其类似化合物，也可以与现有技术的化疗药物或放射治疗联合使用。在一个优选的实施方案中，Gö6976通过阻止癌细胞的形成，作为一种预防性药物用于治疗癌症。
• NOVEL HETEROARYL COMPOUNDS FOR THE MODULATION OF PROTEIN TYROSINE ENZYME RELATED CELLULAR SIGNAL TRANSDUCTION
  申请人：Sugen, Inc.

  公开号：EP1007042A1

  公开（公告）日：2000-06-14
• EP1007042A4
  申请人：——

  公开号：EP1007042A4

  公开（公告）日：2001-07-04
• US5798374A
  申请人：——

  公开号：US5798374A

  公开（公告）日：1998-08-25