trans-N-(benzyloxycarbonyl)-4-carboxy-L-proline methyl ester | 586396-27-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: trans-N-(benzyloxycarbonyl)-4-carboxy-L-proline methyl ester
• 英文别名: (3R,5S)-1-((Benzyloxy)carbonyl)-5-(methoxycarbonyl)pyrrolidine-3-carboxylic acid；(3R,5S)-5-methoxycarbonyl-1-phenylmethoxycarbonylpyrrolidine-3-carboxylic acid
• CAS: 586396-27-2
• 化学式: C₁₅H₁₇NO₆
• 分子量: 307.303
• InChiKey: LRGHQMSTVSRHIH-NEPJUHHUSA-N

物化性质

• 沸点：
  478.6±45.0 °C(Predicted)
• 密度：
  1.348±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.27
• 重原子数：
  22.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  93.14
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  trans-N-(benzyloxycarbonyl)-4-carboxy-L-proline methyl ester 在 碘 、 三乙胺 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 22.0h， 生成 1-dibenzyl 2-dimethyl 4,4'-((3R,8R)-8-formamido-3-((2-methoxy-2-oxoethyl)carbamoyl)-9,12-dioxo-13-oxa-5,6-dithia-2,10-diazatetradecanoyl)(2S,2'S,4R,4'R)-bis(pyrrolidine-1,2-dicarboxylate)
  参考文献：
  名称：

  Proline–Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues

  摘要：

  The two novel diastereoisomeric glutathione analogues I and 2 have been designed and synthesized by replacing the native gamma-glutamylic moiety with the conformational rigid skeleton of cis- or trans-4-carboxy-L-proline residue. Both analogues have been obtained by following the solution phase peptide chemistry methodologies and final reduction of the corresponding disulfide forms 13 and 14. The two analogues 1 and 2 have been tested towards gamma-glutamyltranspeptidase (gamma-GT) and human glutathione S-transferase (hGST P1-1). Both analogues 1 and 2 are completely resistant to enzymatic degradation by gamma-GT. The S-transferase utilizes the analogue 2 as a good substrate while is unable to bind the analogue 1. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00041-5
• 作为产物：
  描述：

  trans-N-(benzyloxycarbonyl)-4-carboxy-L-proline dimethyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以65%的产率得到trans-N-(benzyloxycarbonyl)-4-carboxy-L-proline methyl ester
  参考文献：
  名称：

  Proline–Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues

  摘要：

  The two novel diastereoisomeric glutathione analogues I and 2 have been designed and synthesized by replacing the native gamma-glutamylic moiety with the conformational rigid skeleton of cis- or trans-4-carboxy-L-proline residue. Both analogues have been obtained by following the solution phase peptide chemistry methodologies and final reduction of the corresponding disulfide forms 13 and 14. The two analogues 1 and 2 have been tested towards gamma-glutamyltranspeptidase (gamma-GT) and human glutathione S-transferase (hGST P1-1). Both analogues 1 and 2 are completely resistant to enzymatic degradation by gamma-GT. The S-transferase utilizes the analogue 2 as a good substrate while is unable to bind the analogue 1. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00041-5