(3S,6R)-(6-isopropyl-3-methoxycyclohex-1-enesulfonyl)-benzene | 474022-81-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,6R)-(6-isopropyl-3-methoxycyclohex-1-enesulfonyl)-benzene
• 英文别名: [(3S,6R)-3-methoxy-6-propan-2-ylcyclohexen-1-yl]sulfonylbenzene
• CAS: 474022-81-6
• 化学式: C₁₆H₂₂O₃S
• 分子量: 294.415
• InChiKey: AZLAZINBISAHAL-DZGCQCFKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3S,6R)-(6-isopropyl-3-methoxycyclohex-1-enesulfonyl)-benzene 在 叔丁基锂 、 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 15.42h， 生成 (R)-(-)-cryptone
  参考文献：
  名称：

  Syntheses of Highly Substituted Enantiopure C6 and C7 Enones¹

  摘要：

  Enantiopure epoxyvinyl sulfones SS-9a, SS-9b, produced from Jacobsen epoxidation of 2-phenylsulfonyl 1,3-cyclohexa- and cycloheptadiene, are used as a template for the construction of substituted cycloalkenones and as chiral synthetic equivalents of enones a and b. The addition of carbon nucleophiles to SS-9a, SS-9b is high yielding and stereospecific. Enantiopure alpha,beta- and gamma-substituted cycloalkenones are easily constructed using a variety of methods.

  DOI：

  10.1021/ja026760m
• 作为产物：
  描述：

  (1S,6S)-2-Benzenesulfonyl-7-oxa-bicyclo[4.1.0]hept-2-ene 在 氢氧化钾 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 0.25h， 生成 (3S,6R)-(6-isopropyl-3-methoxycyclohex-1-enesulfonyl)-benzene
  参考文献：
  名称：

  Syntheses of Highly Substituted Enantiopure C6 and C7 Enones¹

  摘要：

  Enantiopure epoxyvinyl sulfones SS-9a, SS-9b, produced from Jacobsen epoxidation of 2-phenylsulfonyl 1,3-cyclohexa- and cycloheptadiene, are used as a template for the construction of substituted cycloalkenones and as chiral synthetic equivalents of enones a and b. The addition of carbon nucleophiles to SS-9a, SS-9b is high yielding and stereospecific. Enantiopure alpha,beta- and gamma-substituted cycloalkenones are easily constructed using a variety of methods.

  DOI：

  10.1021/ja026760m

文献信息

• Syntheses of Highly Substituted Enantiopure C6 and C7 Enones¹
  作者：Jerry Evarts、Eduardo Torres、Philip L. Fuchs

  DOI：10.1021/ja026760m

  日期：2002.9.1

  Enantiopure epoxyvinyl sulfones SS-9a, SS-9b, produced from Jacobsen epoxidation of 2-phenylsulfonyl 1,3-cyclohexa- and cycloheptadiene, are used as a template for the construction of substituted cycloalkenones and as chiral synthetic equivalents of enones a and b. The addition of carbon nucleophiles to SS-9a, SS-9b is high yielding and stereospecific. Enantiopure alpha,beta- and gamma-substituted cycloalkenones are easily constructed using a variety of methods.