N-cyclopentyl-5,6-dihydro-4H-thiazolo[4,5-e]indazol-2-amine | 1235325-29-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-cyclopentyl-5,6-dihydro-4H-thiazolo[4,5-e]indazol-2-amine
• 英文别名: N-cyclopentyl-5,6-dihydro-4H-pyrazolo[4,3-e][1,3]benzothiazol-2-amine
• CAS: 1235325-29-7
• 化学式: C₁₃H₁₆N₄S
• 分子量: 260.363
• InChiKey: NHWYLUKUCWNCRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HETEROTRICYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Boléa Christelle

  公开号：US20110319425A1

  公开（公告）日：2011-12-29

  The present invention relates to novel compounds of Formula (I), wherein X 1 , X 2 , Y, Z 1 , Z 2 , Z 3 , M and (A) m are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.

  本发明涉及式(I)的新型化合物，其中X1、X2、Y、Z1、Z2、Z3、M和（A）如式(I)中所定义；发明化合物是代谢性谷氨酸受体-亚型4（“mGluR4”）的调节剂，可用于治疗或预防中枢神经系统疾病以及其他受mGluR4受体调节的疾病。本发明还涉及制药组合物的制备和使用这种化合物制造药物，以及使用这种化合物预防和治疗涉及mGluR4的疾病。
• US8697744B2
  申请人：——

  公开号：US8697744B2

  公开（公告）日：2014-04-15