(R)-6,6-difluoro-5-{2-fluoro-5-[1-(5-trifluoromethyl-pyridin-2-yl)-1H-imidazol-4-yl]-phenyl}-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine | 1401241-96-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (R)-6,6-difluoro-5-{2-fluoro-5-[1-(5-trifluoromethyl-pyridin-2-yl)-1H-imidazol-4-yl]-phenyl}-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine
• 英文别名: (5R)-6,6-difluoro-5-[2-fluoro-5-[1-[5-(trifluoromethyl)pyridin-2-yl]imidazol-4-yl]phenyl]-5,7,7-trimethyl-2H-1,4-oxazepin-3-amine
• CAS: 1401241-96-0
• 化学式: C₂₃H₂₁F₆N₅O
• 分子量: 497.443
• InChiKey: HGGQOKRGVOPZHV-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS
  申请人：Narquizian Robert

  公开号：US20120253035A1

  公开（公告）日：2012-10-04

  The present invention relates to 1,4 Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

  本发明涉及具有BACE1和/或BACE2抑制活性的1,4噁唑啉的化学式I，其制备、含有它们的药物组合物以及它们作为治疗活性物质的用途。本发明的活性化合物在治疗和/或预防治疗阿尔茨海默病和2型糖尿病等疾病中具有用途。
• [EN] 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS<br/>[FR] 1,4-OXAZÉPINES EN TANT QU'INHIBITEURS DE BACE1 ET/OU BACE2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012136603A1

  公开（公告）日：2012-10-11

  The present invention relates to 1,4 Oxazepines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

  本发明涉及具有BACE1和/或BACE2抑制活性的式(I)的1,4噁唑环化合物，其制备、含有它们的药物组合物以及它们作为治疗活性物质的用途。本发明的活性化合物在治疗和/或预防治疗阿尔茨海默病和2型糖尿病等疾病方面具有用途。
• US8877744B2
  申请人：——

  公开号：US8877744B2

  公开（公告）日：2014-11-04