1-ethyl-5-(4-nitrophenyl)-1H-pyrazole | 942920-13-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-ethyl-5-(4-nitrophenyl)-1H-pyrazole
• 英文别名: 1-Ethyl-5-(4-nitrophenyl)pyrazole
• CAS: 942920-13-0
• 化学式: C₁₁H₁₁N₃O₂
• 分子量: 217.227
• InChiKey: OCLCLNIQEUKEGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  63.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• AZAINDOLE INHIBITORS OF AURORA KINASES
  申请人：DHANAK Dashyant

  公开号：US20070149561A1

  公开（公告）日：2007-06-28

  The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.

  本发明涉及一种由化学式（I）表示的化合物： 及其药学上可接受的盐。本发明的化合物抑制极化激酶，使其特别适用于治疗多种疾病，包括实体肿瘤癌和血液系统癌症。
• Azaindole inhibitors of aurora kinases
  申请人：Dhanak Dashyant

  公开号：US20080306120A1

  公开（公告）日：2008-12-11

  The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.

  本发明涉及一种由式（I）表示的化合物及其药学上可接受的盐。本发明的化合物抑制极化丝激酶，因此特别适用于治疗多种疾病，包括实体瘤癌和血液系统癌症。
• BENZISOXAZOLES
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150259334A1

  公开（公告）日：2015-09-17

  The present invention relates to compounds of general formula wherein Ar 1 /Ar 2 are phenyl or a 5 or 6-membered heteroaryl; R 1 /R 2 is hydrogen, halogen, lower alkyl, CF 3 or lower alkoxy; n,m are 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof, with the exception of the compound 2,1-benzisoxazole, 3-(4-chlorophenyl)-5-(1-phenyl-1H-pyrazol-5 -yl)-. The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.

  本发明涉及一般式为的化合物 其中Ar1/Ar2是苯基或5或6成员杂环基；R1/R2是氢、卤素、低碳基、CF3或低烷氧基；n，m为1或2；或其药学上可接受的酸盐、外消旋体混合物或其相应的对映异构体，但不包括化合物2,1-苯并异噁唑，3-(4-氯苯基)-5-(1-苯基-1H-吡唑-5-基)-。这些化合物可用于治疗精神分裂症、强迫性人格障碍、重度抑郁症、双相情感障碍、焦虑症、正常衰老、癫痫、视网膜退化、创伤性脑损伤、脊髓损伤、创伤后应激障碍、惊恐障碍、帕金森病、痴呆症、阿尔茨海默病、轻度认知障碍、化疗引起的认知功能障碍、唐氏综合症、自闭症谱系障碍、听力损失、耳鸣、脊髓小脑性共济失调、肌萎缩性侧索硬化症、多发性硬化症、亨廷顿病、中风、放射治疗、慢性应激、神经活性药物滥用，如酒精、鸦片类、甲基苯丙胺、邻-二氯苯基环已酮和可卡因。
• US7282588B2
  申请人：——

  公开号：US7282588B2

  公开（公告）日：2007-10-16
• US7419988B2
  申请人：——

  公开号：US7419988B2

  公开（公告）日：2008-09-02