2-Furan-2-yl-4-methyl-thiazole | 14470-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Furan-2-yl-4-methyl-thiazole
• 英文别名: 2-(Furan-2-yl)-4-methyl-1,3-thiazole
• CAS: 14470-84-9
• 化学式: C₈H₇NOS
• 分子量: 165.216
• InChiKey: IYJAHGLMNHLPPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
  申请人：SHY Therapeutics LLC

  公开号：US20170174699A1

  公开（公告）日：2017-06-22

  Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.

  本文提供了抑制MAPK磷酸化的化合物，因此可用于治疗癌症和炎症性疾病的组合物和方法。
• INHIBITORS OF MYOCARDIN-RELATED TRANSCRIPTION FACTOR AND SERUM RESPONSE FACTOR (MRTF/SRF)-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20160145251A1

  公开（公告）日：2016-05-26

  Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor (“MRTF/SRF”), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

  本文披露了抑制由肌动蛋白相关转录因子和血清反应因子或肌动蛋白相关转录因子和血清反应因子（“MRTF / SRF”）介导的基因转录的抑制剂，以及它们在治疗或预防癌症和纤维化方面的使用方法。特别地，本文披露了公式（I）和公式（II）的化合物及其药学上可接受的盐：其中取代基如所述。
• Viral Polymerase Inhibitors
  申请人：TSANTRIZOS Youla S.

  公开号：US20110015203A1

  公开（公告）日：2011-01-20

  An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.

  化合物的对映异构体、顺反异构体或互变异构体，其化学式为I：其中A、B、R1、R2、R3、R4、R5、R6、R7、R8、R9和R10如本文所定义，或其盐或酯，作为HCV NS5B聚合酶的抑制剂。
• VIRAL POLYMERASE INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP1718608B1

  公开（公告）日：2013-07-17
• ORGANIC ELECTROLUMINESCENT DEVICE
  申请人：Kuramochi Yusuke

  公开号：US20120049167A1

  公开（公告）日：2012-03-01

  An organic electroluminescent device in which an organic layer containing a metal coordination compound represented by the following formula (1) is sandwiched between the pair of electrodes composed of an anode and a cathode, ML a X b (1) wherein M is an ion of a metal of Group 11 of the Periodic Table, L is a ligand represented by the formula (2) shown below, X is an anion, and a and b are defined in the specification, wherein A is a divalent group formed by removing two hydrogen atoms from the formula (3) or (4) shown below, and D 1 , k 1 , m 1 , A, D 1 , Q 1 , and Q 2 are defined in the specification, wherein X 1 , X 2 , X 3 , X 4 , X 5 , R 1 , R 5 , R 6 , and R 9 are defined in the specification.