2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[3-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-pyridin-3-yl}-amide | 1229419-10-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {6-[3-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-pyridin-3-yl}-amide
• 英文别名: 2-phenyl-N-[6-[3-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]pyridin-3-yl]-5-(trifluoromethyl)-1,3-oxazole-4-carboxamide
• CAS: 1229419-10-6
• 化学式: C₂₅H₂₃F₃N₆O₃
• 分子量: 512.491
• InChiKey: JZTAYPMFFRPCGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• Inhibitors of Diacylglycerol Acyltransferase
  申请人：Bolin David Robert

  公开号：US20100152445A1

  公开（公告）日：2010-06-17

  Provided herein are amides containing at least a four ring structure, which are inhibitors of diacylglycerol acyltransferase and are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

  本文提供了至少含有四环结构的酰胺，这些酰胺是甘油二酰基转移酶的抑制剂，可用于治疗肥胖、2型糖尿病和代谢综合征等疾病。
• INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE
  申请人：Via Pharmaceuticals, Inc.

  公开号：EP2378878A1

  公开（公告）日：2011-10-26
• US8211914B2
  申请人：——

  公开号：US8211914B2

  公开（公告）日：2012-07-03
• [EN] INHIBITORS OF DIACYLGLYCEROL ACLYTRANSFERASE<br/>[FR] INHIBITEURS DE LA DIACYLGLYCÉROL ACYLTRANSFÉRASE
  申请人：VIA PHARMACEUTICALS INC

  公开号：WO2010077861A1

  公开（公告）日：2010-07-08

  Provided herein are amides containing at least a four ring structure, which are inhibitors of diacylglycerol acyltransferase and are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.