6-(2-pyridyl)methyloxy-3-phenylimidazo[5,1-a]phthalazine | 391197-24-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-(2-pyridyl)methyloxy-3-phenylimidazo[5,1-a]phthalazine
• 英文别名: Imidazo[5,1-a]phthalazine, 3-phenyl-6-(2-pyridinylmethoxy)-；3-phenyl-6-(pyridin-2-ylmethoxy)imidazo[5,1-a]phthalazine
• CAS: 391197-24-3
• 化学式: C₂₂H₁₆N₄O
• 分子量: 352.395
• InChiKey: AFZLNLDXDNORHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Imidazolophthalazine derivatives as ligands for gabaa receptors
  申请人：——

  公开号：US20040147517A1

  公开（公告）日：2004-07-29

  A class of substituted imidazolo[5,1-a]phthalazine derivatives as ligands for GABA A receptors which are partial or full inverse agonists of an &agr;5 receptor subunit while being relatively free of activity at &agr;1 and/or &agr;2 and/or &agr;3 receptor subunit binding sites; they are therefore of benefit as a medicament for enhancing cognition but with the reduction or elimination of procon-vulsant activity.

  一类取代咪唑啉[5,1-a]萘嗪衍生物，作为GABAA受体的配体，它们是α5受体亚单位的部分或完全反向激动剂，同时在α1和/或α2和/或α3受体亚单位结合位点上相对缺乏活性；因此，它们对于增强认知有益，但可以减少或消除抗抗痉挛活性。
• IMIDAZOLOPHTHALAZINE DERIVATIVES AS LIGANDS FOR GABA A? RECEPTORS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1303516A1

  公开（公告）日：2003-04-23
• US6949549B2
  申请人：——

  公开号：US6949549B2

  公开（公告）日：2005-09-27
• [EN] IMIDAZOLOPHTHALAZINE DERIVATIVES AS LIGANDS FOR GABAA RECEPTORS<br/>[FR] DERIVES D'IMIDAZOLOPHTHALAZINE EN TANT QUE LIGANDS POUR DES RECEPTEURS GABAA
  申请人：MERCK SHARP & DOHME

  公开号：WO2002006285A1

  公开（公告）日：2002-01-24

  A class of substituted imidazolo[5,1-a]phthalazine derivatives as ligands for GABAA receptors which are partial or full inverse agonists of an α5 receptor subunit while being relatively free of activity at α1 and/or α2 and/or α3 receptor subunit binding sites; they are therefore of benefit as a medicament for enhancing cognition but with the reduction or elimination of proconvulsant activity.