5-chloro-2-methanesulfinylindan-1-one | 500785-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 5-chloro-2-methanesulfinylindan-1-one
• 英文别名: 5-Chloro-2-methylsulfinyl-2,3-dihydroinden-1-one
• CAS: 500785-14-8
• 化学式: C₁₀H₉ClO₂S
• 分子量: 228.699
• InChiKey: SRPOKSQFBUFKEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  53.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-chloro-2-methylsulfanylindan-1-one 在 sodium periodate 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 5-chloro-2-methanesulfinylindan-1-one
  参考文献：
  名称：

  Use of C2-substituted indan-1-one systems for preparing medicaments for the prophylaxis or treatment of obesity

  摘要：

  本发明实施例涉及减轻哺乳动物体重的方法，以及用于预防或治疗肥胖的方法，包括给予C2-取代的茚-1-酮体系及其生理上可接受的盐和生理功能衍生物。用于本发明实施例方法的化合物可能包括式1的化合物，其中基团如定义所示，以及它们的生理上可接受的盐。

  公开号：

  US20030134882A1

文献信息

• C2-substituted idan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals
  申请人：——

  公开号：US20030130345A1

  公开（公告）日：2003-07-10

  Embodiments of the invention relate to C2-substituted indan-1-ones and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention include compounds of formula I 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.

  该发明的实施例涉及C2-取代的茚烷酮及其生理上可接受的盐和生理功能衍生物。该发明的实施例化合物包括式I1的化合物，其中基团如所定义，并其生理上可接受的盐以及其制备方法。这些化合物例如适用于作为厌食药使用。
• Use of C2-substituted indan-1-ol systems for preparing medicaments for the prophylaxis or treatment of obesity
  申请人：Jaehne Gerhard

  公开号：US20050080057A1

  公开（公告）日：2005-04-14

  Embodiments of the invention relate to methods of reducing weight in mammals and for the prophylaxis or treatment of obesity comprising administration of of C2-substituted indan-1-ol systems and their physiologically acceptable salts and physiologically functional derivatives. Compounds for use in the methods of the embodiments of the invention include compounds of the formula (I) in which the radicals are as defined, and their physiologically acceptable salts.

  本发明实施例涉及减轻哺乳动物体重的方法，以及预防或治疗肥胖的方法，包括给予C2-取代的茚-1-醇体系及其生理上可接受的盐和生理功能衍生物。用于本发明实施例方法的化合物包括式(I)中所定义的基团及其生理上可接受的盐。
• C2-substituted idan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals
  申请人：AVENTIS PHARMA DEUTSCHLAND GMBH

  公开号：US20040068016A1

  公开（公告）日：2004-04-08

  Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.

  本发明的实施例涉及C2取代的茚环-1-醇及其生理上可接受的盐和生理功能衍生物。本发明的化合物可能包括公式I1中所定义的基团及其生理上可接受的盐和制备它们的过程。例如，这些化合物适用于作为食欲抑制剂。
• C2-substituted indan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals
  申请人：——

  公开号：US20030114681A1

  公开（公告）日：2003-06-19

  Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.

  本发明实施例涉及C2取代的茚醇以及其生理上可接受的盐和生理上功能衍生物。本发明实施例的化合物可能包括式I1的化合物，其中基团如定义所述，以及它们的生理上可接受的盐和制备它们的过程。例如，这些化合物适用于用作食欲抑制剂。
• VERWENDUNG VON C2-SUBSTITUIERTEN INDAN-1-OL-SYSTEMEN ZUR HERSTELLUNG VON MEDIKAMENTEN ZUR PROPHYLAXE ODER BEHANDLUNG VON OBESITAS
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1425007A1

  公开（公告）日：2004-06-09