2-(Pyridin-2-yldisulfanyl)ethyl 2-butylsulfanylcarbothioylsulfanyl-2-methylpropanoate | 1541972-42-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(Pyridin-2-yldisulfanyl)ethyl 2-butylsulfanylcarbothioylsulfanyl-2-methylpropanoate
• CAS: 1541972-42-2
• 化学式: C₁₆H₂₃NO₂S₅
• 分子量: 421.694
• InChiKey: CTHDXXRLOBJNPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  173
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,2'-二硫二吡啶 在 4-二甲氨基吡啶 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 24.0h， 生成 2-(Pyridin-2-yldisulfanyl)ethyl 2-butylsulfanylcarbothioylsulfanyl-2-methylpropanoate
  参考文献：
  名称：

  Multifunctional Nanoworms and Nanorods through a One-Step Aqueous Dispersion Polymerization

  摘要：

  Producing synthetic soft worm and rod structures with multiple chemical functionalities on the surface would provide potential utility in drug delivery, nanoreactors, tissue engineering, diagnostics, rheology modifiers, enzyme mimics, and many other applications. Here, we have synthesized multifunctional worms and rods directly in water using a one-step reversible addition-fragmentation chain transfer (RAFT)-mediated dispersion polymerization at high weight fractions of polymer (>10 wt %). The chain-end functionalities included alkyne, pyridyl disulfide, dopamine, beta-thiolactone, and biotin groups. These groups could further be converted or coupled with biomolecules or polymers. We further demonstrated a nanorod colorimetric system with good control over the attachment of fluorescent probes.

  DOI：

  10.1021/ja500092m

文献信息

• ANTIMICROBIAL COMPOUNDS AND NANOSTRUCTURES
  申请人：THE BOEING COMPANY

  公开号：US20180362462A1

  公开（公告）日：2018-12-20

  The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein: Q is fluoro, chloro, bromo, or iodo; each of s, b, and n is independently an integer from about 10 to about 100; and each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

  本公开提供具有一个或多个季铵盐的化合物和纳米结构，包括该化合物和纳米结构的组合物以及使用该化合物、纳米结构和组合物治疗疾病的有用方法。在至少一个方面，化合物由公式（I）表示：或其药学上可接受的盐，其中：Q为氟、氯、溴或碘；每个s、b和n独立地为约10至约100的整数；每个v、j、p、z、q、x和m独立地为1至约20的整数。
• Antimicrobial compounds and nanostructures
  申请人：THE BOEING COMPANY

  公开号：US10428020B2

  公开（公告）日：2019-10-01

  The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein: Q is fluoro, chloro, bromo, or iodo; each of s, b, and n is independently an integer from about 10 to about 100; and each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

  本公开提供了具有一种或多种季铵盐的化合物和纳米结构，包括这些化合物和纳米结构的组合物，以及使用这些化合物、纳米结构和组合物治疗疾病的方法。至少在一个方面，化合物由式 (I) 表示： 或其药学上可接受的盐，其中 Q 是氟、氯、溴或碘； s、b 和 n 各自独立地为约 10 到约 100 的整数；以及 v、j、p、z、q、x 和 m 中的每一个独立地是 1 到 20 左右的整数。
• Temperature-Directed Self-Assembly of Multifunctional Polymeric Tadpoles
  作者：Valentin A. Bobrin、Michael J. Monteiro

  DOI：10.1021/jacs.5b11037

  日期：2015.12.23

  Multicompartment tadpole nano-objects are a rare and intriguing class of structures with potential in a wide range of applications. Here, we demonstrate the synthesis of chemically multifunctional polymer tadpoles made at high weight fractions of polymer (>10 wt %). The tadpoles are synthesized using two different thermoresponsive MacroCTAs with either alkyne or pyridyldisulfide end-groups, allowing chemical functionality in the head, tail, or both. Water-soluble molecules or polymers were coupled to either the head, tail or both without a change in tadpole configuration. In addition, the tadpoles can be dried, rehydrated, and stored in water for 5 months without a change in shape. This method represents a new and an important synthetic development in the design of nano-objects.