1-[1-(5-chloro-2-fluorophenyl)-1H-1,2,3-triazol-4-yl]ethyl methanesulfonate | 925941-04-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[1-(5-chloro-2-fluorophenyl)-1H-1,2,3-triazol-4-yl]ethyl methanesulfonate
• 英文别名: 1-[1-(5-Chloro-2-fluorophenyl)triazol-4-yl]ethyl methanesulfonate
• CAS: 925941-04-4
• 化学式: C₁₁H₁₁ClFN₃O₃S
• 分子量: 319.744
• InChiKey: NWCJJEMVCDWDQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  82.5
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Substituted piperazines as metabotropic glutamate receptor antagonists
  申请人：Edwards Louise

  公开号：US20070037820A1

  公开（公告）日：2007-02-15

  The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar 1 , Ar 2 , Hy, L, R 1 , m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.

  这项发明涉及公式I的化合物或其药用可接受的盐或溶剂： 其中Ar1，Ar2，Hy，L，R1，m和n如描述中所定义。该发明还包括药物组合物及其用途，制备这些化合物的方法，以及治疗mGluR5介导的疾病的方法。
• Substituted Piperazines as Metabotropic Glutamate Receptor Antagonists
  申请人：Edwards Louise

  公开号：US20080312246A1

  公开（公告）日：2008-12-18

  The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar 1 , Ar 2 , Hy, L, R 1 , m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.

  本发明涉及公式I的化合物或其药学上可接受的盐或溶剂：其中Ar1、Ar2、Hy、L、R1、m和n如描述中所定义。本发明还包括药物组合物及其用途，制备该化合物的方法以及治疗mGluR5介导的疾病的方法。