4-oxo-4-[(2,3,4-tri-O-acetyl-β-L-fucopyranosyl)amino]butanoic acid | 839722-27-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-oxo-4-[(2,3,4-tri-O-acetyl-β-L-fucopyranosyl)amino]butanoic acid
• 英文别名: 4-oxo-4-[[(2S,3S,4R,5R,6S)-3,4,5-triacetyloxy-6-methyloxan-2-yl]amino]butanoic acid
• CAS: 839722-27-9
• 化学式: C₁₆H₂₃NO₁₀
• 分子量: 389.359
• InChiKey: XSEATYQCBZOEOM-CPYNQZCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  155
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  丁二酸酐 、 2,3,4-三-O-乙酰基-beta-L-吡喃岩藻糖基叠氮化物 在 4-二甲氨基吡啶 、 palladium on carbon 、 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 4-oxo-4-[(2,3,4-tri-O-acetyl-β-L-fucopyranosyl)amino]butanoic acid
  参考文献：
  名称：

  Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery

  摘要：

  A class of glycolipopeptides for use as building blocks for a new type of dynamic combinatorial library is reported. The members of the library consist of a variable carbohydrate moiety, coded amino acids, and lipoamino acids in order to convert them into amphiphiles. Glycolipopeptidic amphiphiles interact through non-covalent bonding when mixed together in aqueous phase and form micelles in dynamic close-packed fluid mosaic arrays. The head groups of amphiphiles are exposed on the micelle surface, providing entities which could be screened in biological assays to find the most potent combination of building blocks in order to identify new bioactive carbohydrate ligands. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2011.03.019