1-(Cyclopropylmethyl)-4-methyl-5-nitro-1H-imidazole | 1803320-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(Cyclopropylmethyl)-4-methyl-5-nitro-1H-imidazole
• 英文别名: 1-(cyclopropylmethyl)-4-methyl-5-nitroimidazole
• CAS: 1803320-52-6
• 化学式: C8H11N3O2
• 分子量: 181.19
• InChiKey: SVXYYAISAFZAHU-UHFFFAOYSA-N

物化性质

• 沸点：
  369.5±22.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  63.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• GPR142 AGONIST COMPOUNDS
  申请人：Eli Lilly and Company

  公开号：EP3105207A1

  公开（公告）日：2016-12-21
• GPR142 Agonist Compounds
  申请人：Eli Lilly and Company

  公开号：US20170165234A1

  公开（公告）日：2017-06-15

  The present invention provides compounds of the Formula (Ia) wherein R is selected from the group consisting of CH 3 , CH(CH 3 ) 2 , CH 2 CN, CH 2 CHF 2 , CH 2 CF 3 , (A), (B), (C), (D), (E), (F), CH 2 CH 2 OCH 3 , and CH 2 C(O)OCH(CH 3 ) 2 ; R 1 is selected from the group consisting of CF 3 , OCF 3 , and Cl; R 2 is selected from the group consisting of H and F; or a pharmaceutically acceptable salt thereof.
• US9861613B2
  申请人：——

  公开号：US9861613B2

  公开（公告）日：2018-01-09
• [EN] GPR142 AGONIST COMPOUNDS<br/>[FR] COMPOSÉS AGONISTES DU GPR142
  申请人：LILLY CO ELI

  公开号：WO2015120768A1

  公开（公告）日：2015-08-20

  The present invention provides compounds of the Formula (Ia) wherein R is selected from the group consisting of CH3, CH (CH3) 2, CH2CN, CH2CHF2, CH2CF3, (A), (B), (C), (D), (E), (F), CH2CH2OCH3, and CH2C(O)OCH(CH3)2; R1 is selected from the group consisting of CF3, OCF3, and Cl; R2 is selected from the group consisting of H and F; or a pharmaceutically acceptable salt thereof.