19h-4-[3-(4-Chloro-1H-benzoimidazol-2-yl)-1-(4 methoxy-benzyl)-1H-indazol-5-yl]-isoquinoline | 351457-23-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 19h-4-[3-(4-Chloro-1H-benzoimidazol-2-yl)-1-(4 methoxy-benzyl)-1H-indazol-5-yl]-isoquinoline
• 英文别名: 4-[3-(4-chloro-1H-benzimidazol-2-yl)-1-[(4-methoxyphenyl)methyl]indazol-5-yl]isoquinoline
• CAS: 351457-23-3
• 化学式: C₃₁H₂₂ClN₅O
• 分子量: 516.002
• InChiKey: YRWKRQUDYNWXLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  68.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION
  申请人：AGOURON PHARMACEUTICALS, INC.

  公开号：EP1250326A2

  公开（公告）日：2002-10-23
• US7232912B2
  申请人：——

  公开号：US7232912B2

  公开（公告）日：2007-06-19
• [EN] INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR MEDIATING OR INHIBITING CELL PROLIFERATION<br/>[FR] COMPOSES D'INDAZOLE, COMPOSITIONS PHARMACEUTIQUES, ET METHODES DESTINES A LA MEDIATION OU A L'INHIBITION DE LA PROLIFERATION CELLULAIRE
  申请人：AGOURON PHARMA

  公开号：WO2001053268A2

  公开（公告）日：2001-07-26

  Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating , e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.