2-Amino-4-cyclopentyl-thiazol | 936-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Amino-4-cyclopentyl-thiazol
• 英文别名: 4-cyclopentyl-thiazol-2-ylamine；4-Cyclopentylthiazol-2-amine；4-cyclopentyl-1,3-thiazol-2-amine
• CAS: 936-34-5
• 化学式: C₈H₁₂N₂S
• 分子量: 168.263
• InChiKey: CTBIYYQAACIPTJ-UHFFFAOYSA-N

物化性质

• 熔点：
  101-102 °C
• 沸点：
  317.9±11.0 °C(Predicted)
• 密度：
  1.220±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-1-环戊基乙酮 、 硫脲 以 水 为溶剂， 生成 2-Amino-4-cyclopentyl-thiazol
  参考文献：
  名称：

  Smushkevich,Yu.I. et al., Journal of Organic Chemistry USSR (English Translation), 1965, vol. 1, p. 278 - 279

  摘要：

  DOI：

文献信息

• [EN] 2-AMINOTHIAZOLE COMPOUNDS USEFUL AS ASPARTYL PROTEASE INHIBITORS<br/>[FR] COMPOSES DE 2-AMINOTHIAZOLE UTILES EN TANT QU'INHIBITEURS DE L'ASPARTYLE-PROTEASE
  申请人：MERCK & CO INC

  公开号：WO2005097767A1

  公开（公告）日：2005-10-20

  The present invention is directed to 2-aminothiazole compounds which are aspartyl protease inhibitors, and are inhibitors of both the beta-secretase enzyme and HIV protease, and that are useful in the treatment of diseases in which the beta-secretase enzyme and HIV are involved, such as Alzheimer's disease, HIV Infection and AIDS. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme and HIV protease are involved.

  本发明涉及2-氨基噻唑化合物，它们是天冬氨酸蛋白酶抑制剂，同时也是β-分泌酶和HIV蛋白酶的抑制剂，可用于治疗涉及β-分泌酶和HIV的疾病，如阿尔茨海默病、HIV感染和艾滋病。该发明还涉及包含这些化合物的药物组合物，以及在治疗涉及β-分泌酶和HIV蛋白酶的疾病中使用这些化合物和组合物。
• 4-Aryl-pyridine-2-carboxyamide derivatives
  申请人：Jaeschke Georg

  公开号：US20070197553A1

  公开（公告）日：2007-08-23

  The present invention relates to novel pyridine-2-carboxyamide derivatives of formula (I) useful as metabotropic glutamate receptor antagonists: wherein Y, Z, R 1 , R 2 and R 3 are as defined in the specification herein.

  本发明涉及一种新型吡啶-2-羧酰胺衍生物，其化学式为(I)，可用作代谢型谷氨酸受体拮抗剂： 其中Y、Z、R1、R2和R3如本说明书中所定义。
• 2-Aminothiazole Compounds Useful As Aspartyl Protease Inhibitors
  申请人：Coburn A. Craig

  公开号：US20070203147A1

  公开（公告）日：2007-08-30

  The present invention is directed to 2-aminothiazole compounds which are aspartyl protease inhibitors, and are inhibitors of both the beta-secretase enzyme and HIV protease, and that are useful in the treatment of diseases in which the beta-secretase enzyme and HIV are involved, such as Alzheimer's disease, HIV Infection and AIDS. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme and HIV protease are involved.

  本发明涉及2-氨基噻唑化合物，它们是天冬氨酸蛋白酶抑制剂，同时也是β-秘密酶酶和HIV蛋白酶的抑制剂，可用于治疗涉及β-秘密酶酶和HIV的疾病，如阿尔茨海默病、HIV感染和艾滋病。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物治疗涉及β-秘密酶酶和HIV蛋白酶的疾病。
• PYRIDINE-2-CARBOXAMIDE DERIVATIVES
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1987003A1

  公开（公告）日：2008-11-05
• TRPV3 MODULATORS
  申请人：AbbVie Inc.

  公开号：US20180243298A1

  公开（公告）日：2018-08-30

  A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis, eczema, itch or psoriasis, is disclosed. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.