(S)-4-amino-2-(4-(benzyloxy)phenylamino)-N-(piperidin-3-yl)thiazole-5-carboxamide | 1204608-10-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (S)-4-amino-2-(4-(benzyloxy)phenylamino)-N-(piperidin-3-yl)thiazole-5-carboxamide
• 英文别名: 4-amino-2-(4-phenylmethoxyanilino)-N-[(3S)-piperidin-3-yl]-1,3-thiazole-5-carboxamide
• CAS: 1204608-10-5
• 化学式: C₂₂H₂₅N₅O₂S
• 分子量: 423.539
• InChiKey: BYBBWANFDUQNGY-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] 5 -AMIDOTHIAZOLE DERIVATIVES AND THEIR USE AS CHECKPOINT KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE 5-AMIDOTHIAZOLE ET LEUR UTILISATION COMME INHIBITEURS DES CHECKPOINT KINASES
  申请人：CANCER REC TECH LTD

  公开号：WO2010007389A1

  公开（公告）日：2010-01-21

  The present invention pertains to certain thiazole carboxylic acid amide compounds which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function and/or Checkpoint Kinase 2 (CHK2) kinase function, to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHKl kinase function and/or CHK2 kinase function, and in the treatment of diseases and conditions that are mediated by CHKl and/or CHK2, that are ameliorated by the inhibition of CHKl kinase function and/or CHK2 kinase function, such as cancer, optionally in combination with another agent, for example, (a) a DNA topoisomerase I or Il inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or TS inhibitor; (d) a microtubule targeted agent; and (e) ionising radiation.

  本发明涉及某些噻唑羧酸酰胺化合物，其中包括抑制检查点激酶1（CHK1）激酶功能和/或检查点激酶2（CHK2）激酶功能的化合物，以及包含这些化合物的制药组合物，以及这些化合物和组合物在体内外用于抑制CHK1激酶功能和/或CHK2激酶功能，并用于治疗由CHK1和/或CHK2介导的疾病和病况，这些疾病和病况通过抑制CHK1激酶功能和/或CHK2激酶功能得到缓解，例如癌症，可选地与另一种药物联合使用，例如（a）DNA拓扑异构酶I或II抑制剂；（b）DNA损伤剂；（c）抗代谢物或TS抑制剂；（d）微管靶向药物；和（e）电离辐射。