3-Amino-5-ethyl-pyrazol-4-carboxamid | 27511-82-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-Amino-5-ethyl-pyrazol-4-carboxamid
• 英文别名: 3-Amino-5-ethyl-1H-pyrazole-4-carboxamide
• CAS: 27511-82-6
• 化学式: C₆H₁₀N₄O
• mdl: MFCD20617546
• 分子量: 154.172
• InChiKey: YHOWJUKQWKQZCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  97.8
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2188290A1

  公开（公告）日：2010-05-26
• [EN] PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS<br/>[FR] DÉRIVÉS DE PYRAZOLO[3,4-D]-PYRAMIDINE COMME AGENTS ANTIPROLIFÉRATIFS
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009021869A1

  公开（公告）日：2009-02-19

  The present invention is directed to novel pyrazolo[3,4-d]pyrimidine derivatives of the formula (I), and pharmaceutically-acceptable salts and esters thereof, wherein R, Ring A, L, and Ring B are as described herein. These compounds and their pharmaceutically-acceptable salts and esters inhibit Raf kinase and have antiproliferative activity. As such, they are useful in the treatment or control of proliferative disorders such as cancer, in particular solid tumors, more particularly breast tumor, colon tumor, lung tumor, prostate tumor, and melanoma. Also disclosed are a composition and a unit dose formulation comprising such a compound, or a pharmaceutically-acceptable salt or ester thereof, methods for making such compounds, and methods for using such compounds, or their pharmaceutically-acceptable salts or esters, in the treatment of proliferative disorders.