(R)-2-[2-[3-(5-methyl-1,2,4-oxadiazol-3-yl)-phenyl]-1,4-oxazepan-4-yl]-6-(3-fluoropyridin-4-yl)-3-methylpyrimidin-4(3H)-one | 1246455-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (R)-2-[2-[3-(5-methyl-1,2,4-oxadiazol-3-yl)-phenyl]-1,4-oxazepan-4-yl]-6-(3-fluoropyridin-4-yl)-3-methylpyrimidin-4(3H)-one
• 英文别名: 6-(3-fluoropyridin-4-yl)-3-methyl-2-[(2R)-2-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-1,4-oxazepan-4-yl]pyrimidin-4-one
• CAS: 1246455-24-2
• 化学式: C₂₄H₂₃FN₆O₃
• 分子量: 462.483
• InChiKey: PHFYADWBOIXBIZ-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  97
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] 3-[1,4]OXAZEPANE-4-PYRIMIDONE DERIVATIVES<br/>[FR] DÉRIVÉS DE 3-[1,4] OXAZÉPANE-4-PYRIMIDONE
  申请人：MITSUBISHI TANABE PHARMA CORP

  公开号：WO2010114179A1

  公开（公告）日：2010-10-07

  A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom, C-F or the like; R1 represents a C1-C3 alkyl group; Y represents oxygen atom or N-R7; R2, R3, R4, R5, R6 and R7 each independently represents hydrogen atom, a C1-C6 alkyl group, or a group represented by the formula (II): which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

  化合物的化学式为（I）或其药学上可接受的盐：其中Z代表氮原子，C-F或类似物；R1代表C1-C3烷基基团；Y代表氧原子或N-R7；R2、R3、R4、R5、R6和R7分别独立地代表氢原子，C1-C6烷基基团，或由化学式（II）表示的基团：该化合物用于预防和/或治疗由tau蛋白激酶1过度活化引起的疾病，如神经退行性疾病（例如阿尔茨海默病）。
• 3-[1,4]OXAZEPANE-4-PYRIMIDONE DERIVATIVES
  申请人：Watanabe Kazutoshi

  公开号：US20120095216A1

  公开（公告）日：2012-04-19

  A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom, C—F or the like; R 1 represents a C 1 -C 3 alkyl group; Y represents oxygen atom or N—R 7 ; R 2 , R 3 , R 4 , R 5 , R 6 and R 7 each independently represents hydrogen atom, a C 1 -C 6 alkyl group, or a group represented by the formula (II): which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

  化合物的化学式为（I）或其药学上可接受的盐，用于治疗由tau蛋白激酶1过度活化引起的疾病，例如神经退行性疾病（如阿尔茨海默病）。其中，Z代表氮原子、C—F或类似物；R1代表C1-C3烷基；Y代表氧原子或N—R7；R2、R3、R4、R5、R6和R7各自独立地代表氢原子、C1-C6烷基或由式（II）表示的基团。
• US9108957B2
  申请人：——

  公开号：US9108957B2

  公开（公告）日：2015-08-18