4,6-Dibromo-2-(4-methoxyphenyl)pyrimidine | 83217-50-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4,6-Dibromo-2-(4-methoxyphenyl)pyrimidine
• CAS: 83217-50-9
• 化学式: C₁₁H₈Br₂N₂O
• 分子量: 344.005
• InChiKey: COGHZJHXUXXYNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(4-甲氧基苯基)嘧啶 在 溴化氰 、 2,2,6,6-tetramethylpiperidinyl-lithium 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以27%的产率得到4,6-Dibromo-2-(4-methoxyphenyl)pyrimidine
  参考文献：
  名称：

  Diazines 13: Metalation without Ortho-Directing Group - Functionalization of Diazines via Direct Metalation

  摘要：

  The successful metalation of diazines without an ortho-directing group is described. In some cases, dimers were obtained. The metalation was optimal with LTMP if a 4-fold excess of metalating agent was used, with a very short metalation reaction time at -75 degrees C. This procedure was applied to pyrimidine, 2-substituted pyrimidines, pyridazine, and pyrazine, allowing for the synthesis of various monosubstituted diazines.

  DOI：

  10.1021/jo00117a033

文献信息

• Diazines 13: Metalation without Ortho-Directing Group - Functionalization of Diazines via Direct Metalation
  作者：Nelly Ple、Alain Turck、Karine Couture、Guy Queguiner

  DOI：10.1021/jo00117a033

  日期：1995.6

  The successful metalation of diazines without an ortho-directing group is described. In some cases, dimers were obtained. The metalation was optimal with LTMP if a 4-fold excess of metalating agent was used, with a very short metalation reaction time at -75 degrees C. This procedure was applied to pyrimidine, 2-substituted pyrimidines, pyridazine, and pyrazine, allowing for the synthesis of various monosubstituted diazines.