N'-[4-[1-[(4-methylsulfonyl)phenyl]-5-phenyl-1H-pyrazol-3-yl]phenyl]-N'-hydroxyurea | 425418-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N'-[4-[1-[(4-methylsulfonyl)phenyl]-5-phenyl-1H-pyrazol-3-yl]phenyl]-N'-hydroxyurea
• 英文别名: 1-Hydroxy-1-[4-[1-(4-methylsulfonylphenyl)-5-phenylpyrazol-3-yl]phenyl]urea
• CAS: 425418-65-1
• 化学式: C₂₃H₂₀N₄O₄S
• 分子量: 448.502
• InChiKey: SOWABNVKSNFMTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
  申请人：Pharmacia Corporation

  公开号：US20020058810A1

  公开（公告）日：2002-05-16

  This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.

  这项发明属于抗炎药物代理领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶介导的疾病的化合物、组合物和方法，如炎症。
• Pyrazole substituted hydroxamic acid derivatives as cyclooxxgenase-2 and 5- lipoxygenase inhibitors
  申请人：——

  公开号：US20010056189A1

  公开（公告）日：2001-12-27

  This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.

  这项发明属于抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶介导的疾病的化合物、组合物和方法，如炎症。
• Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
  申请人：Pharmacia Corporation

  公开号：US20030176708A1

  公开（公告）日：2003-09-18

  This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.

  这项发明属于抗炎药物领域，具体涉及化合物、组合物和治疗通过环氧合酶-2或5-脂氧合酶介导的疾病的方法，如炎症。
• Pyrazole substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
  申请人：Pharmacia Corporation

  公开号：US20040248943A9

  公开（公告）日：2004-12-09

  This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.

  这项发明属于抗炎药物领域，具体涉及化合物、组合物和治疗通过环氧化酶-2或5-脂氧合酶介导的疾病的方法，如炎症。
• HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS
  申请人：G.D. SEARLE & CO.

  公开号：EP0828718A1

  公开（公告）日：1998-03-18