2-Ethoxycarbonyl-5-(2-bromoethyl)-4-(4-fluorophenyl)thiazole | 204718-68-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Ethoxycarbonyl-5-(2-bromoethyl)-4-(4-fluorophenyl)thiazole
• 英文别名: Ethyl 5-(2-bromoethyl)-4-(4-fluorophenyl)-1,3-thiazole-2-carboxylate
• CAS: 204718-68-3
• 化学式: C₁₄H₁₃BrFNO₂S
• 分子量: 358.231
• InChiKey: ZEDJAOOLHZESPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 2-CARBONYLTHIAZOLE DERIVATIVES AND USE OF THE SAME
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0940401A1

  公开（公告）日：1999-09-08

  This invention provides a 2-carbonylthiazole derivative represented by formula (I): [wherein each of Ar1 and Ar2 represents a phenyl group, a phenyl group having one or two substituents selected from "a halogen atom, an alkyl group having 1 to 5 carbon atoms, a trifluoromethyl group, an alkoxy group having 1 to 5 carbon atoms and a hydroxyl group" or a thienyl group; R1 represents an alkoxy group having 1 to 5 carbon atoms, a hydroxyl group or an amino group represented by formula N(R3)R4 (wherein each of R3 and R4 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, or R3 and R4, together with the nitrogen atom to which they are bound, form a pyrrolidino, piperidino, morpholino or piperazino group, or a pyrrolidino, piperidino, morpholino or piperazino group having one to four substituents selected from "an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms and a hydroxyl group"); Y1-Y2 represents CH-CO or C=C(R2) (wherein R2 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms); and n is an integer of from 1 to 4] or a pharmaceutically acceptable salt thereof. It also provides a medicament which comprises the 2-carbonylthiazole derivative of formula (I) or a pharmaceutically acceptable salt thereof and a dopamine D4 receptor antagonist which contains the same as the active ingredient, which are useful as drugs for preventing and treating dopamine D4 receptor-related morbid states such as schizophrenia and problematic behavior caused by cerebrovascular accidents and senile dementia, and also as the drugs which do not induce extrapyramidal disorders as side effects.

  本发明提供了一种由式(I)代表的2-羰基噻唑衍生物： [其中 Ar1 和 Ar2 各代表一个苯基，一个具有一个或两个取代基的苯基，取代基选自 "卤素原子、具有 1 至 5 个碳原子的烷基、三氟甲基、具有 1 至 5 个碳原子的烷氧基和羟基 "或噻吩基；R1 代表具有 1 至 5 个碳原子的烷氧基、羟基或由式 N(R3)R4 所代表的氨基（其中 R3 和 R4 各代表一个氢原子或具有 1 至 5 个碳原子的烷基，或 R3 和 R4 连同与之结合的氮原子）、形成吡咯烷基、哌啶基、吗啉基或哌嗪基，或吡咯烷基、哌啶基、吗啉基或哌嗪基具有选自 "具有 1 至 5 个碳原子的烷基、具有 1 至 5 个碳原子的烷氧基和羟基 "的 1 至 4 个取代基）；Y1-Y2 代表 CH-CO 或 C=C(R2) （其中 R2 代表氢原子或具有 1 至 5 个碳原子的烷基）；以及 n 是 1 至 4 的整数]或其药学上可接受的盐。本发明还提供了一种药物，该药物包括式（I）的2-羰基噻唑衍生物或其药学上可接受的盐，以及作为活性成分的多巴胺D4受体拮抗剂，该药物可用于预防和治疗与多巴胺D4受体相关的病态，如精神分裂症以及由脑血管意外和老年痴呆症引起的行为问题，同时也是不会诱发锥体外系障碍作为副作用的药物。
• US6166033A
  申请人：——

  公开号：US6166033A

  公开（公告）日：2000-12-26