2-tert-butyl-4-(3,4-dichlorophenyl)-1H-imidazole | 1010836-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-tert-butyl-4-(3,4-dichlorophenyl)-1H-imidazole
• 英文别名: 2-tert-butyl-5-(3,4-dichlorophenyl)-1H-imidazole
• CAS: 1010836-04-0
• 化学式: C₁₃H₁₄Cl₂N₂
• 分子量: 269.174
• InChiKey: YKNFEBGDTAYTME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• IMIDAZOLE DERIVATIVES
  申请人：Osakada Naoto

  公开号：US20100152178A1

  公开（公告）日：2010-06-17

  A CB2 receptor modulator comprising an imidazole derivative represented by the general formula (I): [wherein, R 1 represents optionally substituted lower alkyl or the like; R 2 represents optionally substituted cycloalkyl or the like; R 3 represents optionally substituted aryl or the like; and n represents an integer of 0 to 3] or a pharmaceutically acceptable salt thereof as an active ingredient, and the like are provided.

  提供一种CB2受体调节剂，其包含由通式（I）表示的咪唑衍生物[其中，R1代表可选取代的低碳基或类似物；R2代表可选取代的环烷基或类似物；R3代表可选取代的芳基或类似物；n代表0至3的整数]或其药学上可接受的盐作为活性成分等。
• Purine diones as Wnt pathway modulators
  申请人：Agency for Science, Technology and Research

  公开号：US10472360B2

  公开（公告）日：2019-11-12

  The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

  本发明涉及一般结构(I)化合物在调节 Wnt 通路中的用途[此处应插入式子] 其中 R1、R2、R3、R4 和 R5 各自独立地为 H 或烷基； D 选自 H、卤素、烷基、环烷基、芳基和二烷基氨基组成的组，每种基团（H 和卤素除外）均被任选取代；Ar 是芳基或杂芳基，任选被取代；Cy 是芳基、杂芳基或含有至少一个杂原子的饱和环，每种基团均被任选取代；以及 n 是 1 至 3 的整数。
• IMIDAZOLE DERIVATIVE
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP2090570B1

  公开（公告）日：2011-11-09
• Purine Diones As Wnt Pathway Modulators
  申请人：Agency for Science, Technology and Research

  公开号：US20170334912A1

  公开（公告）日：2017-11-23

  The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R 1 , R 2 , R 3 , R 4 and R 5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
• US8273738B2
  申请人：——

  公开号：US8273738B2

  公开（公告）日：2012-09-25