2-Amino-1-[1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-4-phenyl-1H-pyrrole-3-carbonitrile | 344359-48-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-Amino-1-[1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-4-phenyl-1H-pyrrole-3-carbonitrile
• CAS: 344359-48-4
• 化学式: C₂₁H₂₁N₃O₂
• 分子量: 347.417
• InChiKey: VFADYHBAACEEIV-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-Amino-1-[1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-4-phenyl-1H-pyrrole-3-carbonitrile 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 生成 2-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3-(4-methoxy-phenyl)-propan-1-ol
  参考文献：
  名称：

  7-Alkyl- and 7-Cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines—potent inhibitors of the tyrosine kinase c-Src

  摘要：

  7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from alpha -bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60(c-Src) with good specificity towards other tyrosine kinases (EGF-R, v-Abl). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00079-8
• 作为产物：
  描述：

  2-amino-3-(4-methoxyphenyl)-1-propanol 在 sodium ethanolate 、 N,N-二异丙基乙胺 作用下， 以 乙醇 为溶剂， 生成 2-Amino-1-[1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-4-phenyl-1H-pyrrole-3-carbonitrile
  参考文献：
  名称：

  7-Alkyl- and 7-Cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines—potent inhibitors of the tyrosine kinase c-Src

  摘要：

  7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from alpha -bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60(c-Src) with good specificity towards other tyrosine kinases (EGF-R, v-Abl). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00079-8