2-acetamido-9-((6aR,8R,9R,9aR)-9-iodo-2,2,4,4-tetraisopropyl-6a-((triethylsilyl)ethynyl)tetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl diphenylcarbamate | 1320269-89-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-acetamido-9-((6aR,8R,9R,9aR)-9-iodo-2,2,4,4-tetraisopropyl-6a-((triethylsilyl)ethynyl)tetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl diphenylcarbamate
• CAS: 1320269-89-3
• 化学式: C₄₅H₆₃IN₆O₆SSi₃
• 分子量: 1027.26
• InChiKey: NVNGKQGZQZRTGA-LMCUSSQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.92
• 重原子数：
  62.0
• 可旋转键数：
  12.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  129.93
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  2-acetamido-9-((6aR,8R,9R,9aR)-9-iodo-2,2,4,4-tetraisopropyl-6a-((triethylsilyl)ethynyl)tetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl diphenylcarbamate 在 三乙基硼 、 四丁基氟化铵 、 氧气 、 三正丁基氢锡 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 42.0h， 生成
  参考文献：
  名称：

  Synthesis of 4′-Ethynyl-2′-deoxy-4′-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI

  摘要：

  The synthesis of 4'-ethynyl-2'-deoxy-4'-thioribonucleosides was carried out utilizing an electrophilic glycosidation in which 4-ethynyl-4-thiofuranoid glycal 16 served as a glycosyl donor. Electrophilic glycosidation between 16 and the silylated nucleobases (N-4-acetylcytosine, N-6-benzoyladenine, and N-2-acetyl-O-6-diphenylcarbamoylguanine) was carried out in the presence of N-iodosuccinimide (NIS), leading to the exclusive formation of the desired beta-anomers 29, 33, and 36. Anti-HIV studies demonstrated that these 4'-thio nucleosides were less cytotoxic to T-lymphocyte (i.e., MT-4 cells) than the corresponding 4'-ethynyl derivatives of 2'-deoxycytidine (44), 2'-deoxyadenosine (45), and 2'-deoxyguanosine (46). Comparison of the selectivity indices (SI) was made between 4'-thionucleosides (32, 41, and 43) and the corresponding 4'-oxygen analogues 44-46 by using the reported CC50 and EC50 values. In the case of cytosine and adenine nucleosides, comparable SI values were obtained as follows: 32 (545) and 44 (458); 41 (>230) and 45 (1630). In contrast, 4'-ethynyl-2'-deoxy-4'-thioguanosine 43 was found to possess a SI value of >18200, which is 20 times better than that of 46 (933).

  DOI：

  10.1021/ml2001054
• 作为产物：
  描述：

  N,N-二苯基-氨基甲酸 2-(乙酰氨基)-9H-嘌呤-6-基酯 在 N-碘代丁二酰亚胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 24.0h， 生成 2-acetamido-1-((6aR,8R,9R,9aR)-9-iodo-2,2,4,4-tetraisopropyl-6a-((triethylsilyl)ethynyl)tetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1H-purin-6-yl diphenylcarbamate 、 、 2-acetamido-9-((6aR,8R,9R,9aR)-9-iodo-2,2,4,4-tetraisopropyl-6a-((triethylsilyl)ethynyl)tetrahydro-6H-thieno[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl diphenylcarbamate
  参考文献：
  名称：

  Synthesis of 4′-Ethynyl-2′-deoxy-4′-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI

  摘要：

  The synthesis of 4'-ethynyl-2'-deoxy-4'-thioribonucleosides was carried out utilizing an electrophilic glycosidation in which 4-ethynyl-4-thiofuranoid glycal 16 served as a glycosyl donor. Electrophilic glycosidation between 16 and the silylated nucleobases (N-4-acetylcytosine, N-6-benzoyladenine, and N-2-acetyl-O-6-diphenylcarbamoylguanine) was carried out in the presence of N-iodosuccinimide (NIS), leading to the exclusive formation of the desired beta-anomers 29, 33, and 36. Anti-HIV studies demonstrated that these 4'-thio nucleosides were less cytotoxic to T-lymphocyte (i.e., MT-4 cells) than the corresponding 4'-ethynyl derivatives of 2'-deoxycytidine (44), 2'-deoxyadenosine (45), and 2'-deoxyguanosine (46). Comparison of the selectivity indices (SI) was made between 4'-thionucleosides (32, 41, and 43) and the corresponding 4'-oxygen analogues 44-46 by using the reported CC50 and EC50 values. In the case of cytosine and adenine nucleosides, comparable SI values were obtained as follows: 32 (545) and 44 (458); 41 (>230) and 45 (1630). In contrast, 4'-ethynyl-2'-deoxy-4'-thioguanosine 43 was found to possess a SI value of >18200, which is 20 times better than that of 46 (933).

  DOI：

  10.1021/ml2001054