N'-((2-hydroxynaphthalen-1-yl)methylene)-2-oxo-2H-chromene-3-carbohydrazide | 1264282-74-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N'-((2-hydroxynaphthalen-1-yl)methylene)-2-oxo-2H-chromene-3-carbohydrazide
• CAS: 1264282-74-7
• 化学式: C₂₁H₁₄N₂O₄
• 分子量: 358.353
• InChiKey: FDFHALKOQFMRKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  27.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.9
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  6-溴香豆素-3-甲酸乙酯 在 盐酸 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 10.0h， 生成 N'-((2-hydroxynaphthalen-1-yl)methylene)-2-oxo-2H-chromene-3-carbohydrazide
  参考文献：
  名称：

  Synthesis, characterization, in vitro antimicrobial and DNA cleavage studies of Co(II), Ni(II) and Cu(II) complexes with ONOO donor coumarin Schiff bases

  摘要：

  A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized with Schiff bases derived from 2-hydroxy-1-naphthaldehyde and 2-oxo-2H-chromene-3-carbohydrazide/6-bromo-2-oxo-2H-chromene-3-carbohydrazide. The chelation of the complexes has been proposed in the light of analytical, spectral (IR, UV-Vis, H-1 NMR, ESR, FAB-mass and fluorescence), magnetic and thermal studies. The measured molar conductance values indicate that, the complexes are non-electrolytic in nature. The redox behavior of the complexes was investigated with electrochemical method by using cyclic voltammetry. The Schiff bases and their metal complexes have been screened for their in vitro antibacterial (Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella typhi) and antifungal activities (Candida albicans, Cladosporium and Aspergillus niger) by MIC method. The DNA cleavage is studied by agarose gel electrophoresis method. (c) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2010.11.016