3-(1-(3-(N,N-dimethylsulfamoyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-N,N-dimethylbenzenesulfonamide | 1352319-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(1-(3-(N,N-dimethylsulfamoyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-N,N-dimethylbenzenesulfonamide
• 英文别名: 3-[[1-[3-(dimethylsulfamoyl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,N-dimethylbenzenesulfonamide
• CAS: 1352319-17-5
• 化学式: C₂₁H₂₃N₇O₄S₂
• 分子量: 501.59
• InChiKey: RNTVPHQTSPMPOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS
  申请人：Woller Kevin R.

  公开号：US20120015963A1

  公开（公告）日：2012-01-19

  The present disclosure is directed to novel compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.

  本公开涉及公式（I）的新化合物，其中所述变量如定义所述，其药学上可接受的盐、前药、生物活性代谢物、立体异构体和同分异构体。公式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些情况和疾病，特别是炎症性疾病和增殖性疾病和情况，例如类风湿性关节炎、系统性红斑狼疮、多发性硬化症、克罗恩病、银屑病和哮喘。
• US8637529B2
  申请人：——

  公开号：US8637529B2

  公开（公告）日：2014-01-28