acetic acid-(α,β-dichloro-isopropyl ester) | 89416-37-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetic acid-(α,β-dichloro-isopropyl ester)
• 英文别名: Essigsaeure-(α,β-dichlor-isopropylester)；Essigsaeure-<1,2-dichlor-propyl-(2)-ester>；1,3-Dichloroisopropyl acetate；1,2-dichloropropan-2-yl acetate
• CAS: 89416-37-5
• 化学式: C₅H₈Cl₂O₂
• 分子量: 171.023
• InChiKey: IRHULXVERSLUEJ-UHFFFAOYSA-N

物化性质

• 沸点：
  45-46 °C(Press: 41 Torr)
• 密度：
  1.2158 g/cm3
• 保留指数：
  1026

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  acetic acid-(α,β-dichloro-isopropyl ester) 、 硫脲 在 水 作用下， 生成 2-氨基-4-甲基噻唑
  参考文献：
  名称：

  Process for preparing 4-substituted thiazoles

  摘要：

  公开号：

  US02404416A1
• 作为产物：
  描述：

  乙酸异丙烯酯 在 氯 作用下， 生成 acetic acid-(α,β-dichloro-isopropyl ester)
  参考文献：
  名称：

  Hagemeyer; Hull, Industrial and Engineering Chemistry, 1949, vol. 41, p. 2921

  摘要：

  DOI：

文献信息

• Conversion of a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin
  申请人：DOW GLOBAL TECHNOLOGIES INC.

  公开号：EP2174925A1

  公开（公告）日：2010-04-14

  A process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

  一种将多羟基化脂肪烃或其酯转化为氯醇的工艺，其方法是将多羟基化脂肪烃或其酯起始原料与超大气压分压的氯化氢源在足够的时间和足够的温度下进行接触，并且在不大量脱水的情况下进行这种收缩步骤，以生产所需的氯醇产品；其中可以高产率生产所需的一种或多种产品，而不会大量形成不需要的过氯副产品。此外，本发明的某些催化剂可在超大气压、大气压和亚大气压条件下用于本发明的工艺中，并取得更好的效果。
• Conversion of a multihydroxylated aliphatic hydrocarbon or ester thereof to a chlorohydrin
  申请人：DOW GLOBAL TECHNOLOGIES INC.

  公开号：EP2181979A1

  公开（公告）日：2010-05-05

  A process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

  一种将多羟基化脂肪烃或其酯转化为氯醇的工艺，其方法是将多羟基化脂肪烃或其酯起始原料与超大气压分压的氯化氢源在足够的时间和足够的温度下进行接触，并且在不大量脱水的情况下进行这种收缩步骤，以生产所需的氯醇产品；其中可以高产率生产所需的一种或多种产品，而不会大量形成不需要的过氯副产品。此外，本发明的某些催化剂可在超大气压、大气压和亚大气压条件下用于本发明的工艺中，并取得更好的效果。
• CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN
  申请人：DOW GLOBAL TECHNOLOGIES INC.

  公开号：EP1771403B1

  公开（公告）日：2010-01-06
• Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloracetone levels
  申请人：Kruper J. William

  公开号：US20080015369A1

  公开（公告）日：2008-01-17

  The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of hydrogen chloride at superatmospheric, atmospheric and subatmospheric pressure conditions for a sufficient time and at a sufficient temperature, preferably wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; said process carried out without a step undertaken to specifically remove volatile chlorinated hydrocarbon by-products or chloroacetone, wherein the combined concentration of volatile chlorinated hydrocarbon by-products and chloroacetone is less than 2000 ppm throughout any stage of the said process.
• Process for the conversion of a crude glycerol, crude mixtures of naturally derived multicomponent aliphatic hydrocarbons or esters thereof to a chlorohydrin
  申请人：Hook D. Bruce

  公开号：US20080015370A1

  公开（公告）日：2008-01-17

  A process for converting a crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof to a chlorohydrin, by contacting the crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; wherein said crude glycerol, said ester of crude glycerol, or mixture thereof is derived from a renewable raw material. Chlorohydrins made by the process of the present invention are useful in preparing epoxides such as epichlorohydrins.